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Attention-deficit/hyperactivity disorder (ADHD) is associated with altered functioning in multiple cognitive domains and neural networks. This paper offers an overarching biological perspective across these. We applied a novel strategy that extracts functional connectivity modulations in the brain across one (P_single), two (P_mix) or three (P_all) cognitive tasks and compared the pattern of modulations between participants with ADHD (n-89), unaffected siblings (n = 93) and controls (n = 84; total N = 266; age range = 8–27 years). Participants with ADHD had significantly fewer P_all connections (modulated regardless of task), but significantly more task-specific (P_single) connectivity modulations than the other groups. The amplitude of these P_single modulations was significantly higher in ADHD. Unaffected siblings showed a similar degree of P_all connectivity modulation as controls but a similar degree of P_single …