Authors
Dennis van der Meer, Pieter J Hoekstra, Daan van Rooij, Anderson M Winkler, Hanneke van Ewijk, Dirk J Heslenfeld, Jaap Oosterlaan, Stephen V Faraone, Barbara Franke, Jan K Buitelaar, Catharina A Hartman
Publication date
2018/8/18
Journal
The World Journal of Biological Psychiatry
Volume
19
Issue
6
Pages
450-460
Publisher
Taylor & Francis
Description
Objectives: Individuals with attention-deficit/hyperactivity disorder (ADHD) often have heightened levels of anxiety, which has been associated with worse performance on working memory tasks. Knowledge of the neural pathways underlying the combined presence of ADHD and anxiety may aid in a better understanding of their co-occurrence. Therefore, we investigated how anxiety modulates the effect of ADHD severity on neural activity during a visuospatial working memory (VSWM) task.
Methods: Neuroimaging data were available for 371 adolescents and young adults participating in the multicentre cohort study NeuroIMAGE (average age 17.1 years). We analysed the effects of ADHD severity, anxiety severity and their interaction on-task accuracy, and on neural activity associated with working memory (VSWM trials minus baseline), and memory load (high memory load trials minus low load trials).
Results …
Scholar articles
D van der Meer, PJ Hoekstra, D van Rooij, AM Winkler… - The World Journal of Biological Psychiatry, 2018