Authors
Claudia L Satizabal, Hieab HH Adams, Derrek P Hibar, Charles C White, Maria J Knol, Jason L Stein, Markus Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady V Roshchupkin, Albert V Smith, Joshua C Bis, Xueqiu Jian, Michelle Luciano, Edith Hofer, Alexander Teumer, Sven J Van Der Lee, Jingyun Yang, Lisa R Yanek, Tom V Lee, Shuo Li, Yanhui Hu, Jia Yu Koh, John D Eicher, Sylvane Desrivières, Alejandro Arias-Vasquez, Ganesh Chauhan, Lavinia Athanasiu, Miguel E Rentería, Sungeun Kim, David Hoehn, Nicola J Armstrong, Qiang Chen, Avram J Holmes, Anouk Den Braber, Iwona Kloszewska, Micael Andersson, Thomas Espeseth, Oliver Grimm, Lucija Abramovic, Saud Alhusaini, Yuri Milaneschi, Martina Papmeyer, Tomas Axelsson, Stefan Ehrlich, Roberto Roiz-Santiañez, Bernd Kraemer, Asta K Håberg, Hannah J Jones, G Bruce Pike, Dan J Stein, Allison Stevens, Janita Bralten, Meike W Vernooij, Tamara B Harris, Irina Filippi, A Veronica Witte, Tulio Guadalupe, Katharina Wittfeld, Thomas H Mosley, James T Becker, Nhat Trung Doan, Saskia P Hagenaars, Yasaman Saba, Gabriel Cuellar-Partida, Najaf Amin, Saima Hilal, Kwangsik Nho, Nazanin Mirza-Schreiber, Konstantinos Arfanakis, Diane M Becker, David Ames, Aaron L Goldman, Phil H Lee, Dorret I Boomsma, Simon Lovestone, Sudheer Giddaluru, Stephanie Le Hellard, Manuel Mattheisen, Marc M Bohlken, Dalia Kasperaviciute, Lianne Schmaal, Stephen M Lawrie, Ingrid Agartz, Esther Walton, Diana Tordesillas-Gutierrez, Gareth E Davies, Jean Shin, Jonathan C Ipser, Louis N Vinke, Martine Hoogman, Tianye Jia, Ralph Burkhardt, Marieke Klein, Fabrice Crivello, Deborah Janowitz, Owen Carmichael, Unn K Haukvik, Benjamin S Aribisala, Helena Schmidt, Lachlan T Strike, Ching-Yu Cheng, Shannon L Risacher, Benno Pütz, Debra A Fleischman, Amelia A Assareh, Venkata S Mattay, Randy L Buckner, Patrizia Mecocci, Anders M Dale, Sven Cichon, Marco P Boks, Mar Matarin, Brenda WJH Penninx, Vince D Calhoun, M Mallar Chakravarty, Andre F Marquand, Christine Macare, Shahrzad Kharabian Masouleh, Jaap Oosterlaan, Philippe Amouyel, Katrin Hegenscheid, Jerome I Rotter, Andrew J Schork, David CM Liewald, Greig I De Zubicaray, Tien Yin Wong, Li Shen, Philipp G Sämann, Henry Brodaty, Joshua L Roffman, Eco JC De Geus, Magda Tsolaki, Susanne Erk, Kristel R Van Eijk, Gianpiero L Cavalleri, Nic JA Van Der Wee, Andrew M McIntosh, Randy L Gollub, Kazima B Bulayeva, Manon Bernard, Jennifer S Richards, Jayandra J Himali, Markus Loeffler, Nanda Rommelse, Wolfgang Hoffmann, Lars T Westlye, Maria C Valdés Hernández, Narelle K Hansell, Theo GM Van Erp
Publication date
2019/11
Journal
Nature genetics
Volume
51
Issue
11
Pages
1624-1636
Publisher
Nature Publishing Group US
Description
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting …
Scholar articles
CL Satizabal, HHH Adams, DP Hibar, CC White… - Nature genetics, 2019