Authors
Dennis van der Meer, Tobias Kaufmann, Aldo Córdova-Palomera, Francesco Bettella, Oleksandr Frei, N Trung Doan, Dag Alnæs, Torgeir Moberget, Ingrid Agartz, Alessandro Bertolino, Christine L Brandt, Jan K Buitelaar, Srdjan Djurovic, Erlend D Dørum, Thomas Espeseth, Stephen V Faraone, Barbara Franke, Asta Håberg, Beathe C Haatveit, Catharina Hartman, Stephanie Le Hellard, Dirk Heslenfeld, Pieter Hoekstra, Erik G Jönsson, Knut Kolskår, Martina J Lund, Ingrid Melle, Linn B Norbom, Jan E Nordvik, Lars Nyberg, Jaap Oosterlaan, Andreas Papassotiropoulos, Giulio Pergola, Genevieve Richard, Anne-Marthe Sanders, Vidar M Steen, Kristine M Ulrichsen, Ole Andreassen, Lars T Westlye
Publication date
2018/5/1
Journal
Biological Psychiatry
Volume
83
Issue
9
Pages
S257
Publisher
Elsevier
Description
Background
The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are known to be differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often found to be impaired in individuals with brain disorders associated with reduced hippocampal volume, including Alzheimer's disease (AD) and schizophrenia. Given these structural and functional differences, we sought to characterize the subfields’ shared and specific genetic architecture.
Methods
T1-images (n= 17418, 16 cohorts) were processed with the hippocampal subfields algorithm in FreeSurfer v6. 0. We calculated the SNP-based heritability of 12 subfields, as well as their genetic correlation with each other, with other structural brain features, and with AD and schizophrenia. We further ran a genome-wide association analysis on each subfield …
Scholar articles
D van der Meer, T Kaufmann, A Córdova-Palomera… - Biological Psychiatry, 2018