Authors
Merel C Postema, Martine Hoogman, Sara Ambrosino, Philip Asherson, Tobias Banaschewski, Cibele E Bandeira, Alexandr Baranov, Claiton HD Bau, Sarah Baumeister, Ramona Baur‐Streubel, Mark A Bellgrove, Joseph Biederman, Janita Bralten, Daniel Brandeis, Silvia Brem, Jan K Buitelaar, Geraldo F Busatto, Francisco X Castellanos, Mara Cercignani, Tiffany M Chaim‐Avancini, Kaylita C Chantiluke, Anastasia Christakou, David Coghill, Annette Conzelmann, Ana I Cubillo, Renata B Cupertino, Patrick De Zeeuw, Alysa E Doyle, Sarah Durston, Eric A Earl, Jeffery N Epstein, Thomas Ethofer, Damien A Fair, Andreas J Fallgatter, Stephen V Faraone, Thomas Frodl, Matt C Gabel, Tinatin Gogberashvili, Eugenio H Grevet, Jan Haavik, Neil A Harrison, Catharina A Hartman, Dirk J Heslenfeld, Pieter J Hoekstra, Sarah Hohmann, Marie F Høvik, Terry L Jernigan, Bernd Kardatzki, Georgii Karkashadze, Clare Kelly, Gregor Kohls, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Sara Lera‐Miguel, Klaus‐Peter Lesch, Mario R Louza, Astri J Lundervold, Charles B Malpas, Paulo Mattos, Hazel McCarthy, Leyla Namazova‐Baranova, Rosa Nicolau, Joel T Nigg, Stephanie E Novotny, Eileen Oberwelland Weiss, Ruth L O'Gorman Tuura, Jaap Oosterlaan, Bob Oranje, Yannis Paloyelis, Paul Pauli, Felipe A Picon, Kerstin J Plessen, J Antoni Ramos‐Quiroga, Andreas Reif, Liesbeth Reneman, Pedro GP Rosa, Katya Rubia, Anouk Schrantee, Lizanne JS Schweren, Jochen Seitz, Philip Shaw, Tim J Silk, Norbert Skokauskas, Juan C Soliva Vila, Michael C Stevens, Gustavo Sudre, Leanne Tamm, Fernanda Tovar‐Moll, Theo GM Van Erp, Alasdair Vance, Oscar Vilarroya, Yolanda Vives‐Gilabert, Georg G Von Polier, Susanne Walitza, Yuliya N Yoncheva, Marcus V Zanetti, Georg C Ziegler, David C Glahn, Neda Jahanshad, Sarah E Medland, ENIGMA ADHD Working Group, Paul M Thompson, Simon E Fisher, Barbara Franke, Clyde Francks
Publication date
2021/10
Journal
Journal of Child Psychology and Psychiatry
Volume
62
Issue
10
Pages
1202-1219
Description
Objective
Some studies have suggested alterations of structural brain asymmetry in attention‐deficit/hyperactivity disorder (ADHD), but findings have been contradictory and based on small samples. Here, we performed the largest ever analysis of brain left‐right asymmetry in ADHD, using 39 datasets of the ENIGMA consortium.
Methods
We analyzed asymmetry of subcortical and cerebral cortical structures in up to 1,933 people with ADHD and 1,829 unaffected controls. Asymmetry Indexes (AIs) were calculated per participant for each bilaterally paired measure, and linear mixed effects modeling was applied separately in children, adolescents, adults, and the total sample, to test exhaustively for potential associations of ADHD with structural brain asymmetries.
Results
There was no evidence for altered caudate nucleus asymmetry in ADHD, in contrast to prior literature. In children, there was less rightward …
Scholar articles
MC Postema, M Hoogman, S Ambrosino, P Asherson… - Journal of Child Psychology and Psychiatry, 2021