Authors
Siri DS Noordermeer, Marjolein Luman, Corina U Greven, Kim Veroude, Stephen V Faraone, Catharina A Hartman, Pieter J Hoekstra, Barbara Franke, Jan K Buitelaar, Dirk J Heslenfeld, Jaap Oosterlaan
Publication date
2017/11/1
Journal
Biological Psychiatry
Volume
82
Issue
9
Pages
642-650
Publisher
Elsevier
Description
Background
Attention-deficit/hyperactivity disorder (ADHD) is associated with structural abnormalities in total gray matter, basal ganglia, and cerebellum. Findings of structural abnormalities in frontal and temporal lobes, amygdala, and insula are less consistent. Remarkably, the impact of comorbid oppositional defiant disorder (ODD) (comorbidity rates up to 60%) on these neuroanatomical differences is scarcely studied, while ODD (in combination with conduct disorder) has been associated with structural abnormalities of the frontal lobe, amygdala, and insula. The aim of this study was to investigate the effect of comorbid ODD on cerebral volume and cortical thickness in ADHD.
Methods
Three groups, 16 ± 3.5 years of age (mean ± SD; range 7–29 years), were studied on volumetric and cortical thickness characteristics using structural magnetic resonance imaging (surface-based morphometry): ADHD+ODD (n = 67 …
Scholar articles
SDS Noordermeer, M Luman, CU Greven, K Veroude… - Biological Psychiatry, 2017