Authors
Rachel M Brouwer, Neeltje EM van Haren, Marta Di Forti, Leonard H van den Berg, Brenda WJH Penninx, Peter G Falkai, Ingrid Agartz, Berend Malchow, Gary Donohoe, Tilo Kircher, Javier Vázquez-Bourgon, Juliane H Fröhner, Celso Arango, Henk-Jan Westeneng, Sintia I Belangero, Andreas J Forstner, Paola Dazzan, Temmuz Karali, Giovanni A Salum, Philip R Jansen, Dirk J Heslenfeld, Rene S Kahn, Paul M Thompson, Katrina L Grasby, Covadonga M Díaz-Caneja, Carol E Franz, Svenja Caspers, Vicente Medel, Philip B Mitchell, Arun LW Bokde, Stephanie H Witt, Laura KM Han, William S Kremen, Tonya White, Sophia I Thomopoulos, Philip Shaw, John BJ Kwok, Andreas Heinz, Erik G Jönsson, Rhoshel K Lenroot, Hugo G Schnack, Gunter Schumann, Andreas Jansen, Ole A Andreassen, Penny A Gowland, Antoine Grigis, Jason L Stein, Joanna K Bright, Nicola J Armstrong, Robin M Murray, Nikita Setiaman, Janik Goltermann, Ronny Redlich, Tim Hahn, Dorret I Boomsma, Dag Alnæs, Dennis van der Meer, Leila Nabulsi, Kang Sim, Susanne Meinert, Igor Nenadic, Jan K Buitelaar, Jan H Veldink, Markus M Nöthen, Stephanie Le Hellard, Sergi Papiol, Mohammad A Ikram, Nils Opel, Linda Ding, Dara M Cannon, Kristel R van Eijk, Daniel Keeser, Wei Wen, Frauke Nees, Margaret J Wright, Gareth J Barker, Ulrik F Malt, Marcos L Santoro, Pieter J Hoekstra, Marcella Rietschel, Catharina A Hartman, Loes M Olde Loohuis, Dennis van’t Ent, Katharina Wittfeld, Mayuresh S Korgaonkar, Karen A Mather, Bernhard T Baune, Vidar M Steen, Sylvane Desrivières, Hieab HH Adams, Roel A Ophoff, Jalmar Teeuw, Matthew S Panizzon, Elizabeth EL Buimer, Luise Poustka, Sarah J Heany, Rodrigo A Bressan, Bronwyn J Overs, Frederike Stein, Jiyang Jiang, Katrin Amunts, Tobias Banaschewski, Sarah E Medland, Christienne G Damatac, Benedicto Crespo Facorro, Nicolas A Crossley, Rick M Tankard, Derek W Morris, Clara Alloza, Elena Shumskaya, Aad van der Lugt, Yuri Milaneschi, Andre Zugman, Evangelos Vassos, Elisabet Blok, Julian Trollor, Christiane Jockwitz, Robin Bülow, Jonathan Repple, Ryan L Muetzel, Thomas W Mühleisen, Torbjørn Elvsåshagen, Manon Hillegers, Wiepke Cahn, Martijn GJC Koevoets, Simon E Fisher, Jacqueline Hoare, Casper L de Mol, Udo Dannlowski, Christopher D Whelan, Barbara Franke, Simone Ciufolini, Marieke Klein, Sonja Zwarte, Erin B Quinlan, Dan J Stein, Marie-Laure Paillère Martinot, Jaap Oosterlaan, Dominik Grotegerd, Henrik Walter, Jean-Luc Martinot, Nitin Gogtay, Hans J Grabe, Erlend Bøen, Maria J Knol, Eric Artiges, Lars T Westlye, Michael N Smolka, Hilleke E Hulshoff Pol, Herta Flor
Publication date
2020
Issue
FZJ-2020-04005
Publisher
Strukturelle und funktionelle Organisation des Gehirns
Description
Human brain structure changes throughout our lives. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental, and neurodegenerative diseases. While heritable, specific loci in the genome that influence these rates are largely unknown. Here, we sought to find common genetic variants that affect rates of brain growth or atrophy, in the first genome-wide association analysis of longitudinal changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 10,163 individuals aged 4 to 99 years, on average 3.5 years apart, were used to compute rates of morphological change for 15 brain structures. We discovered 5 genome-wide significant loci and 15 genes associated with brain structural changes. Most individual variants exerted age-dependent effects. All identified genes are expressed in fetal and adult brain tissue, and some exhibit …
Scholar articles
RM Brouwer, NEM van Haren, MD Forti… - 2020