Authors
Annabeth P Groenman, Lizanne JS Schweren, Wouter Weeda, Marjolein Luman, Siri DS Noordermeer, Dirk J Heslenfeld, Barbara Franke, Stephen V Faraone, Nanda Rommelse, Catharina A Hartman, Pieter J Hoekstra, Jan Buitelaar, Jaap Oosterlaan
Publication date
2019/9
Journal
European child & adolescent psychiatry
Volume
28
Pages
1213-1222
Publisher
Springer Berlin Heidelberg
Description
Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of developing substance use disorders (SUDs) and nicotine dependence (ND). It remains unclear whether and how stimulant treatment may affect this risk. We aimed to investigate how stimulant use profiles influence the risk of SUDs and ND, using a novel data-driven community detection analysis to construct different stimulant use profiles. Comprehensive lifetime stimulant prescription data and data on SUDs and ND were available for 303 subjects with ADHD and 219 controls, with a mean age 16.3 years. Community detection was used to define subgroups based on multiple indicators of treatment history, start age, treatment duration, total dose, maximum dose, variability, stop age. In stimulant-treated participants, three subgroups with distinct medication trajectories were distinguished (late-and-moderately dosed, n …
Scholar articles
AP Groenman, LJS Schweren, W Weeda, M Luman… - European child & adolescent psychiatry, 2019