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L Miguel Martins
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Mammalian caspases: structure, activation, substrates, and functions during apoptosis
WC Earnshaw, LM Martins, SH Kaufmann
Annual review of biochemistry 68 (1), 383-424, 1999
40511999
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
KM Strauss, LM Martins, H Plun-Favreau, FP Marx, S Kautzmann, D Berg, ...
Human molecular genetics 14 (15), 2099-2111, 2005
7382005
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
LM Martins, I Iaccarino, T Tenev, S Gschmeissner, NF Totty, NR Lemoine, ...
Journal of Biological Chemistry 277 (1), 439-444, 2002
7292002
Links between air pollution and COVID-19 in England
M Travaglio, Y Yu, R Popovic, L Selley, NS Leal, LM Martins
Environmental pollution 268, 115859, 2021
6252021
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
H Plun-Favreau, K Klupsch, N Moisoi, S Gandhi, S Kjaer, D Frith, ...
Nature cell biology 9 (11), 1243-1252, 2007
5722007
PINK1 cleavage at position A103 by the mitochondrial protease PARL
E Deas, H Plun-Favreau, S Gandhi, H Desmond, S Kjaer, SHY Loh, ...
Human molecular genetics 20 (5), 867-879, 2011
5162011
Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
LM Martins, A Morrison, K Klupsch, V Fedele, N Moisoi, P Teismann, ...
Molecular and cellular biology, 2004
4972004
The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner
J Zhao, T Tenev, LM Martins, J Downward, NR Lemoine
Journal of cell science 113 (23), 4363-4371, 2000
4332000
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions
CM Eischen, TJ Kottke, LM Martins, GS Basi, JS Tung, WC Earnshaw, ...
Blood, The Journal of the American Society of Hematology 90 (3), 935-943, 1997
3251997
Involvement of FADD and caspase-8 signalling in detachment-induced apoptosis
M Rytömaa, LM Martins, J Downward
Current Biology 9 (18), S1-S2, 1999
2701999
Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells
RT Lima, LM Martins, JE Guimaraes, C Sambade, MH Vasconcelos
Cancer gene therapy 11 (5), 309-316, 2004
2642004
Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis
LM Martins, T Kottke, PW Mesner, GS Basi, S Sinha, N Frigon, E Tatar, ...
Journal of Biological Chemistry 272 (11), 7421-7430, 1997
2391997
The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death
S Baksh, S Tommasi, S Fenton, CY Victor, LM Martins, GP Pfeifer, F Latif, ...
Molecular cell 18 (6), 637-650, 2005
2302005
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
N Moisoi, K Klupsch, V Fedele, P East, S Sharma, A Renton, ...
Cell Death & Differentiation 16 (3), 449-464, 2009
2012009
Cancer and neurodegeneration: between the devil and the deep blue sea
H Plun-Favreau, PA Lewis, J Hardy, LM Martins, NW Wood
PLoS genetics 6 (12), e1001257, 2010
1792010
Progressive motor neuron pathology and the role of astrocytes in a human stem cell model of VCP-related ALS
CE Hall, Z Yao, M Choi, GE Tyzack, A Serio, R Luisier, J Harley, E Preza, ...
Cell reports 19 (9), 1739-1749, 2017
1782017
Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis
LM Martins, PW Mesner, TJ Kottke, GS Basi, S Sinha, JS Tung, ...
Blood, The Journal of the American Society of Hematology 90 (11), 4283-4296, 1997
1731997
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease
I Celardo, AC Costa, S Lehmann, C Jones, N Wood, NE Mencacci, ...
Cell death & disease 7 (6), e2271-e2271, 2016
1652016
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease
R Tufi, S Gandhi, IP De Castro, S Lehmann, PR Angelova, D Dinsdale, ...
Nature cell biology 16 (2), 157, 2014
1612014
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi
LM Martins, BE Turk, V Cowling, A Borg, ET Jarrell, LC Cantley, ...
Journal of Biological Chemistry 278 (49), 49417-49427, 2003
1582003
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