| Rational approaches to improving selectivity in drug design DJ Huggins, W Sherman, B Tidor Journal of medicinal chemistry 55 (4), 1424-1444, 2012 | 360 | 2012 |
| Overcoming chemical, biological, and computational challenges in the development of inhibitors targeting protein-protein interactions L Laraia, G McKenzie, DR Spring, AR Venkitaraman, DJ Huggins Chemistry & biology 22 (6), 689-703, 2015 | 157 | 2015 |
| Biomolecular simulations: From dynamics and mechanisms to computational assays of biological activity DJ Huggins, PC Biggin, MA Dämgen, JW Essex, SA Harris, ... Wiley Interdisciplinary Reviews: Computational Molecular Science 9 (3), e1393, 2019 | 150 | 2019 |
| PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair H Khoury-Haddad, N Guttmann-Raviv, I Ipenberg, D Huggins, ... Proceedings of the National Academy of Sciences 111 (7), E728-E737, 2014 | 142 | 2014 |
| A role for glycine in the gating of plant NMDA‐like receptors C Dubos, D Huggins, GH Grant, MR Knight, MM Campbell The Plant Journal 35 (6), 800-810, 2003 | 142 | 2003 |
| Rational methods for the selection of diverse screening compounds DJ Huggins, AR Venkitaraman, DR Spring ACS chemical biology 6 (3), 208-217, 2011 | 129 | 2011 |
| Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues N Kastan, K Gnedeva, T Alisch, AA Petelski, DJ Huggins, J Chiaravalli, ... Nature communications 12 (1), 3100, 2021 | 96 | 2021 |
| Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2 M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, ... Scientific Reports 6 (1), 28528, 2016 | 94 | 2016 |
| International union of basic and clinical pharmacology. CVII. Structure and pharmacology of the apelin receptor with a recommendation that elabela/toddler is a second … C Read, D Nyimanu, TL Williams, DJ Huggins, P Sulentic, RGC Macrae, ... Pharmacological reviews 71 (4), 467-502, 2019 | 88 | 2019 |
| Quantifying the entropy of binding for water molecules in protein cavities by computing correlations DJ Huggins Biophysical journal 108 (4), 928-936, 2015 | 79 | 2015 |
| Correlations in liquid water for the TIP3P-Ewald, TIP4P-2005, TIP5P-Ewald, and SWM4-NDP models DJ Huggins The Journal of chemical physics 136 (6), 2012 | 69 | 2012 |
| The function of the amino terminal domain in NMDA receptor modulation DJ Huggins, GH Grant Journal of Molecular Graphics and Modelling 23 (4), 381-388, 2005 | 67 | 2005 |
| Characterization and tissue‐specific expression of two lepidopteran farnesyl diphosphate synthase homologs: Implications for the biosynthesis of ethyl‐substituted juvenile hormones M Cusson, C Béliveau, SE Sen, S Vandermoten, RG Rutledge, D Stewart, ... Proteins: Structure, function, and bioinformatics 65 (3), 742-758, 2006 | 66 | 2006 |
| Systematic placement of structural water molecules for improved scoring of protein–ligand interactions DJ Huggins, B Tidor Protein Engineering, Design & Selection 24 (10), 777-789, 2011 | 60 | 2011 |
| Thermodynamic properties of water molecules at a protein–protein interaction surface DJ Huggins, M Marsh, MC Payne Journal of chemical theory and computation 7 (11), 3514-3522, 2011 | 55 | 2011 |
| Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance MK Parai, DJ Huggins, H Cao, MNL Nalam, A Ali, CA Schiffer, B Tidor, ... Journal of medicinal chemistry 55 (14), 6328-6341, 2012 | 53 | 2012 |
| Assessing the accuracy of inhomogeneous fluid solvation theory in predicting hydration free energies of simple solutes DJ Huggins, MC Payne The Journal of Physical Chemistry B 117 (27), 8232-8244, 2013 | 46 | 2013 |
| Estimating Translational and Orientational Entropies Using the k-Nearest Neighbors Algorithm DJ Huggins Journal of Chemical Theory and Computation 10 (9), 3617-3625, 2014 | 45 | 2014 |
| Combining solvent thermodynamic profiles with functionality maps of the Hsp90 binding site to predict the displacement of water molecules K Haider, DJ Huggins Journal of chemical information and modeling 53 (10), 2571-2586, 2013 | 45 | 2013 |
| Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells E Mullarky, J Xu, AD Robin, DJ Huggins, A Jennings, N Noguchi, A Olland, ... Bioorganic & medicinal chemistry letters 29 (17), 2503-2510, 2019 | 44 | 2019 |
David R SpringUniversity of CambridgeVerified email at ch.cam.ac.uk
