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Nicholas J Haradhvala
Nicholas J Haradhvala
The Broad Institute
Verified email at broadinstitute.org
Title
Cited by
Cited by
Year
The repertoire of mutational signatures in human cancer
LB Alexandrov, J Kim, NJ Haradhvala, MN Huang, AW Tian Ng, Y Wu, ...
Nature 578 (7793), 94-101, 2020
23382020
Pan-cancer analysis of whole genomes
Nature 578 (7793), 82-93, 2020
1671*2020
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
E Rheinbay, MM Nielsen, F Abascal, JA Wala, O Shapira, G Tiao, ...
Nature 578 (7793), 102-111, 2020
4972020
A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer
P Polak, J Kim, LZ Braunstein, R Karlic, NJ Haradhavala, G Tiao, ...
Nature genetics 49 (10), 1476-1486, 2017
4832017
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
K Yizhak, F Aguet, J Kim, JM Hess, K Kübler, J Grimsby, R Frazer, ...
Science 364 (6444), eaaw0726, 2019
4332019
Mutational strand asymmetries in cancer genomes reveal mechanisms of DNA damage and repair
NJ Haradhvala, P Polak, P Stojanov, KR Covington, E Shinbrot, JM Hess, ...
Cell 164 (3), 538-549, 2016
4072016
Structural alterations driving castration-resistant prostate cancer revealed by linked-read genome sequencing
SR Viswanathan, G Ha, AM Hoff, JA Wala, J Carrot-Zhang, CW Whelan, ...
Cell 174 (2), 433-447. e19, 2018
3142018
Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution
S Kasar, J Kim, R Improgo, G Tiao, P Polak, N Haradhvala, MS Lawrence, ...
Nature communications 6 (1), 8866, 2015
2682015
Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma
O Zavidij, NJ Haradhvala, TH Mouhieddine, R Sklavenitis-Pistofidis, S Cai, ...
Nature cancer 1 (5), 493-506, 2020
2452020
The repertoire of mutational signatures in human cancer
LB Alexandrov, J Kim, NJ Haradhvala, MN Huang, AWT Ng, Y Wu, A Boot, ...
BioRxiv, 322859, 2018
1742018
CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours
RC Larson, MC Kann, SR Bailey, NJ Haradhvala, PM Llopis, AA Bouffard, ...
Nature 604 (7906), 563-570, 2022
1682022
Distinct mutational signatures characterize concurrent loss of polymerase proofreading and mismatch repair
NJ Haradhvala, J Kim, YE Maruvka, P Polak, D Rosebrock, D Livitz, ...
Nature communications 9 (1), 1746, 2018
1612018
Analysis of somatic microsatellite indels identifies driver events in human tumors
YE Maruvka, KW Mouw, R Karlic, P Parasuraman, A Kamburov, P Polak, ...
Nature biotechnology 35 (10), 951-959, 2017
1202017
Scaling computational genomics to millions of individuals with GPUs
A Taylor-Weiner, F Aguet, NJ Haradhvala, S Gosai, S Anand, J Kim, ...
Genome biology 20, 1-5, 2019
1162019
Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma
Nature Medicine, 1848–1859, 2022
932022
Passenger hotspot mutations in cancer
JM Hess, A Bernards, J Kim, M Miller, A Taylor-Weiner, NJ Haradhvala, ...
Cancer Cell 36 (3), 288-301. e14, 2019
702019
DNA polymerase and mismatch repair exert distinct microsatellite instability signatures in normal and malignant human cells
J Chung, YE Maruvka, S Sudhaman, J Kelly, NJ Haradhvala, V Bianchi, ...
Cancer discovery 11 (5), 1176-1191, 2021
522021
Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes
E Rheinbay, MM Nielsen, F Abascal, G Tiao, H Hornshøj, JM Hess, ...
BioRxiv, 237313, 2017
472017
Group PMSW, Getz G, Rozen SG, Stratton MR, Consortium P. The repertoire of mutational signatures in human cancer
LB Alexandrov, J Kim, NJ Haradhvala, MN Huang, AW Tian Ng, Y Wu, ...
Nature 578 (7793), 94-101, 2020
432020
Combined burden and functional impact tests for cancer driver discovery using DriverPower
S Shuai, S Gallinger, LD Stein
Nature communications 11 (1), 734, 2020
372020
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Articles 1–20