| Two distinct pools of B12 analogs reveal community interdependencies in the ocean KR Heal, W Qin, F Ribalet, AD Bertagnolli, W Coyote-Maestas, LR Hmelo, ... Proceedings of the National Academy of Sciences 114 (2), 364-369, 2017 | 177 | 2017 |
| Targeted insertional mutagenesis libraries for deep domain insertion profiling W Coyote-Maestas, D Nedrud, S Okorafor, Y He, D Schmidt Nucleic Acids Research, 2019 | 36 | 2019 |
| Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning W Coyote-Maestas, D Nedrud, Y He, D Schmidt Elife 11, e76903, 2022 | 35 | 2022 |
| Domain insertion permissibility-guided engineering of allostery in ion channels W Coyote-Maestas, Y He, CL Myers, D Schmidt Nature communications 10 (1), 1-14, 2019 | 29 | 2019 |
| DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology CB Macdonald, D Nedrud, PR Grimes, D Trinidad, JS Fraser, ... Genome biology 24 (1), 36, 2023 | 28* | 2023 |
| Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling W Coyote-Maestas, D Nedrud, A Suma, Y He, KA Matreyek, DM Fowler, ... Nature communications 12 (1), 7114, 2021 | 24 | 2021 |
| A large‐scale survey of pairwise epistasis reveals a mechanism for evolutionary expansion and specialization of PDZ domains D Nedrud, W Coyote‐Maestas, D Schmidt Proteins: Structure, Function, and Bioinformatics 89 (8), 899-914, 2021 | 18 | 2021 |
| Profiling the proximal proteome of the activated μ-opioid receptor BJ Polacco, BT Lobingier, EE Blythe, N Abreu, P Khare, MK Howard, ... Nature Chemical Biology, 1-11, 2024 | 11* | 2024 |
| The full spectrum of SLC22 OCT1 mutations illuminates the bridge between drug transporter biophysics and pharmacogenomics SW Yee, CB Macdonald, D Mitrovic, X Zhou, ML Koleske, J Yang, ... Molecular Cell 84 (10), 1932-1947. e10, 2024 | 7* | 2024 |
| Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain GO Estevam, EM Linossi, CB Macdonald, CA Espinoza, JM Michaud, ... bioRxiv, 2023 | 7 | 2023 |
| Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage J Rao, R Xin, C Macdonald, MK Howard, GO Estevam, SW Yee, M Wang, ... Genome Biology 25 (1), 138, 2024 | 4 | 2024 |
| DIMPLE library generation and assembly protocol C Macdonald, D Nedrud, PR Grimes, D Trinidad, J Fraser, ... | 1 | 2023 |
| Molecular basis of proton-sensing by G protein-coupled receptors MK Howard, N Hoppe, XP Huang, CB Macdonald, E Mehrota, PR Grimes, ... bioRxiv, 2024 | | 2024 |
| Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning GO Estevam, EM Linossi, J Rao, CB Macdonald, A Ravikumar, ... bioRxiv, 2024.07. 16.603579, 2024 | | 2024 |
| Defining and Reducing Variant Classification Disparities M Dawood, S Fayer, S Pendyala, M Post, D Kalra, K Patterson, E Venner, ... medRxiv, 2024.04. 11.24305690, 2024 | | 2024 |
| O01: Using multiplexed functional data to reduce the VUS burden in populations underrepresented in genomic medicine M Dawood, S Fayer, M Post, D Kalra, K Patterson, E Venner, L Muffley, ... Genetics in Medicine Open 2, 2024 | | 2024 |
| Deep insertional mutagenesis and multiplex assessment of phenotype reveals biophysical mechanisms of protein domain compatibility D Schmidt, W Coyote-Maestas, D Nedrud, M Hoffmann Biophysical Journal 121 (3), 156a, 2022 | | 2022 |
| Using deep mutational scanning to identify the determinants of antibiotic resistance CB Macdonald, A Kelley, J Pellegrino, W Coyote-Maestas, J Fraser Biophysical Journal 121 (3), 422a, 2022 | | 2022 |
| Deconvoluting receptor trafficking, regulation, and function using massively parallel assays D Nedrud, Y He, D Schmidt, J Fraser, W Coyote-Maestas Biophysical Journal 121 (3), 2a, 2022 | | 2022 |
| The Biophysical basis of protein domain compatibility D Schmidt, W Coyote-Maestas, D Nedrud, A Suma, Y He, KA Matreyek, ... PROTEIN SCIENCE 30, 73-74, 2021 | | 2021 |
