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Stephen J. Polyak
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Year
Two-way pharmacodynamic modeling of drug combinations and its application to pairs of repurposed Ebola and SARS-CoV-2 agents
S Xu, S Esmaeili, EF Cardozo-Ojeda, A Goyal, JM White, SJ Polyak, ...
Antimicrobial Agents and Chemotherapy, e01015-23, 2024
2024
A unifying model to explain high nirmatrelvir therapeutic efficacy, low post-exposure prophylaxis efficacy, and frequent viral rebound
S Esmaeili, K Owens, J Wagoner, SJ Polyak, JM White, JT Schiffer
medRxiv, 2024
2024
Antiviral efficacy of approved antiviral drugs and combinations thereof against CHIKV in human skin fibroblasts and AG129 mice
S Verwimp, R Abdelnabi, J Neyts, SJ Polyak, L Delang
European Meeting on Viral Zoonoses, Location: Saint-Raphael, France, 2023
2023
A unifying model to explain nirmatrelvir/ritonavir’s high efficacy during early treatment and low efficacy as post-exposure prophylaxis, and to predict viral rebound
S Esmaeili, K Owens, J Wagoner, SJ Polyak, JT Schiffer
32023
Inhibition of arenaviruses by combinations of approved therapeutic drugs
SJ Polyak, S Herring, J Wagoner, J White
US Patent App. 17/998,800, 2023
2023
Latent tuberculosis is associated with heightened levels of pro-and anti-inflammatory cytokines among Kenyan men and women living with HIV on long-term antiretroviral therapy
TM Temu, SJ Polyak, CN Wanjalla, NA Mandela, S Dabee, JN Mogaka, ...
AIDS 37 (7), 1065-1075, 2023
32023
Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents
A Khadilkar, ZL Bunch, J Wagoner, V Ravindran, JM Oda, WS Vidar, ...
Journal of Natural Products 86 (4), 1061-1073, 2023
32023
Virology under the microscope—a call for rational discourse
F Goodrum, AC Lowen, S Lakdawala, J Alwine, A Casadevall, ...
Journal of virology 97 (2), e00089-23, 2023
112023
A unifying model to explain nirmatrelvir/ritonavir's high efficacy during early treatment and low efficacy as post-exposure prophylaxis, and to predict viral rebound
SS Esmaeili-Wellman, K Owens, J Wagoner, SJ Polyak, JT Schiffer
medRxiv, 2023.08. 23.23294505, 2023
12023
Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network
V Ravindran, J Wagoner, P Athanasiadis, AB Den Hartigh, JM Sidorova, ...
Briefings in Bioinformatics 23 (6), bbac456, 2022
12022
Combinations of host-and virus-targeting antiviral drugs confer synergistic suppression of SARS-CoV-2
J Wagoner, S Herring, TY Hsiang, A Ianevski, SB Biering, S Xu, ...
Microbiology spectrum 10 (5), e03331-22, 2022
192022
Mono-and combinational drug therapies for global viral pandemic preparedness
A Ianevski, R Yao, RM Simonsen, V Myhre, E Ravlo, GD Kaynova, ...
Iscience 25 (4), 2022
182022
Broad-spectrum mono-and combinational drug therapies for global viral pandemic preparedness
A Ianevski, R Yao, RM Simonsen, V Myhre, E Ravlo, GD Kaynova, ...
bioRxiv, 2022.01. 15.476444, 2022
22022
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
JM White, JT Schiffer, RA Bender Ignacio, S Xu, D Kainov, A Ianevski, ...
MBio 12 (6), e03347-21, 2021
442021
Evaluation of the potential of botanicals and their constituents against the SARS-CoV-2 virus
NB Cech, A Khadilkar, J Wagoner, T Clark, P Manwill, Z Bunch, D Todd, ...
Planta Medica 87 (15), KN10, 2021
2021
Human immunodeficiency virus is associated with higher levels of systemic inflammation among Kenyan adults despite viral suppression
SJ Masyuko, ST Page, SJ Polyak, J Kinuthia, AO Osoti, FC Otieno, ...
Clinical Infectious Diseases 73 (7), e2034-e2042, 2021
92021
Central obesity is a contributor to systemic inflammation and monocyte activation in virally suppressed adults with chronic HIV in Kenya
TM Temu, J Wagoner, S Masyuko, A O’Connor, JS Zifodya, P Macharia, ...
AIDS 35 (11), 1723-1731, 2021
32021
Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants
MS Nair, Y Huang, DA Fidock, SJ Polyak, J Wagoner, MJ Towler, ...
Journal of ethnopharmacology 274, 114016, 2021
1142021
Inhibition of arenaviruses by combinations of orally available approved drugs
S Herring, JM Oda, J Wagoner, D Kirchmeier, A O’Connor, EA Nelson, ...
Antimicrobial agents and chemotherapy 65 (4), 10.1128/aac. 01146-20, 2021
342021
CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice
D Stone, KR Long, MA Loprieno, HSDS Feelixge, EJ Kenkel, RM Liley, ...
Molecular Therapy-Methods & Clinical Development 20, 258-275, 2021
702021
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