| An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution J Dai, TS Dexheimer, D Chen, M Carver, A Ambrus, RA Jones, D Yang Journal of the American Chemical Society 128 (4), 1096-1098, 2006 | 475 | 2006 |
| Deconvoluting the Structural and Drug-Recognition Complexity of the G-Quadruplex-Forming Region Upstream of the bcl-2 P1 Promoter TS Dexheimer, D Sun, LH Hurley Journal of the American Chemical Society 128 (16), 5404-5415, 2006 | 440 | 2006 |
| A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses Q Liang, TS Dexheimer, P Zhang, AS Rosenthal, MA Villamil, C You, ... Nature chemical biology 10 (4), 298-304, 2014 | 236 | 2014 |
| Selective and cell-active inhibitors of the USP1/UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells J Chen, TS Dexheimer, Y Ai, Q Liang, MA Villamil, J Inglese, DJ Maloney, ... Chemistry & biology 18 (11), 1390-1400, 2011 | 225 | 2011 |
| Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition MV Gormally, TS Dexheimer, G Marsico, DA Sanders, C Lowe, ... Nature communications 5 (1), 5165, 2014 | 200 | 2014 |
| Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells J Murai, NH Shar-yin, BB Das, TS Dexheimer, S Takeda, Y Pommier Journal of Biological Chemistry 287 (16), 12848-12857, 2012 | 192 | 2012 |
| Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy WC Stafford, X Peng, MH Olofsson, X Zhang, DK Luci, L Lu, Q Cheng, ... Science translational medicine 10 (428), eaaf7444, 2018 | 186 | 2018 |
| Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy TS Dexheimer, S Antony, C Marchand, Y Pommier Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal …, 2008 | 186 | 2008 |
| DNA repair pathways and mechanisms TS Dexheimer DNA repair of cancer stem cells, 19-32, 2013 | 171 | 2013 |
| Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA‐PK BB Das, S Antony, S Gupta, TS Dexheimer, CE Redon, S Garfield, ... The EMBO journal 28 (23), 3667-3680, 2009 | 169 | 2009 |
| Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria BB Das, TS Dexheimer, K Maddali, Y Pommier Proceedings of the National Academy of Sciences 107 (46), 19790-19795, 2010 | 157 | 2010 |
| A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells GH Nguyen, TS Dexheimer, AS Rosenthal, WK Chu, DK Singh, ... Chemistry & biology 20 (1), 55-62, 2013 | 154 | 2013 |
| NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1 TS Dexheimer, SS Carey, S Zuohe, VM Gokhale, X Hu, LB Murata, ... Molecular cancer therapeutics 8 (5), 1363-1377, 2009 | 131 | 2009 |
| DNA cleavage assay for the identification of topoisomerase I inhibitors TS Dexheimer, Y Pommier Nature protocols 3 (11), 1736-1750, 2008 | 121 | 2008 |
| TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs SN Huang, J Murai, I Dalla Rosa, TS Dexheimer, A Naumova, ... Nucleic acids research 41 (16), 7793-7803, 2013 | 99 | 2013 |
| Design, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents E Kiselev, TS Dexheimer, Y Pommier, M Cushman Journal of medicinal chemistry 53 (24), 8716-8726, 2010 | 95 | 2010 |
| Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors MA Cinelli, A Morrell, TS Dexheimer, ES Scher, Y Pommier, M Cushman Journal of medicinal chemistry 51 (15), 4609-4619, 2008 | 94 | 2008 |
| Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization A Morrell, M Placzek, S Parmley, S Antony, TS Dexheimer, Y Pommier, ... Journal of medicinal chemistry 50 (18), 4419-4430, 2007 | 89 | 2007 |
| 7-azaindenoisoquinolines as topoisomerase I inhibitors and potential anticancer agents E Kiselev, S DeGuire, A Morrell, K Agama, TS Dexheimer, Y Pommier, ... Journal of medicinal chemistry 54 (17), 6106-6116, 2011 | 88 | 2011 |
| Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay C Marchand, WA Lea, A Jadhav, TS Dexheimer, CP Austin, J Inglese, ... Molecular cancer therapeutics 8 (1), 240-248, 2009 | 87 | 2009 |
