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Jasper van der Aart
Jasper van der Aart
Director & Head of Oncology Clinical Imaging, GSK
Verified email at gsk.com - Homepage
Title
Cited by
Cited by
Year
Within-Subject Comparison of [11C]-( + )-PHNO and [11C]raclopride Sensitivity to Acute Amphetamine Challenge in Healthy Humans
P Shotbolt, AC Tziortzi, GE Searle, A Colasanti, J Van Der Aart, ...
Journal of Cerebral Blood Flow & Metabolism 32 (1), 127-136, 2012
1442012
Testing the effects of Δ9-THC and D-cycloserine on extinction of conditioned fear in humans
F Klumpers, D Denys, JL Kenemans, C Grillon, J van der Aart, JMP Baas
Journal of Psychopharmacology, 2012
882012
Prediction of repeat-dose occupancy from single-dose data: characterisation of the relationship between plasma pharmacokinetics and brain target occupancy
S Abanades, J Van Der Aart, JAR Barletta, C Marzano, GE Searle, ...
Journal of Cerebral Blood Flow & Metabolism 31 (3), 944-952, 2011
612011
Radiation dose estimates for carbon-11-labelled PET tracers
J van der Aart, WA Hallett, EA Rabiner, J Passchier, RA Comley
Nuclear medicine and biology 39 (2), 305-314, 2012
492012
Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised …
K Recourt, J van der Aart, G Jacobs, M de Kam, W Drevets, L van Nueten, ...
Journal of Psychopharmacology 34 (9), 1030-1042, 2020
362020
Monoamine transporter occupancy of a novel triple reuptake inhibitor in baboons and humans using positron emission tomography
RA Comley, CA Salinas, M Slifstein, M Petrone, C Marzano, I Bennacef, ...
Journal of Pharmacology and Experimental Therapeutics 346 (2), 311-317, 2013
182013
Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine
C Bakker, J van der Aart, EP Hart, ES Klaassen, KR Bergmann, ...
Alzheimer's & Dementia: Translational Research & Clinical Interventions 6 (1 …, 2020
122020
Evaluation of the novel PET tracer [11C]HACH242 for imaging the GluN2B NMDA receptor in non-human primates
J van der Aart, M Yaqub, EJM Kooijman, J Bakker, JAM Langermans, ...
Molecular Imaging and Biology 21 (4), 676-685, 2019
112019
First in human evaluation of [18F]PK-209, a PET ligand for the ion channel binding site of NMDA receptors
J van der Aart, SSV Golla, M van der Pluijm, LA Schwarte, RC Schuit, ...
EJNMMI research 8 (1), 1-12, 2018
112018
Brain exposure of osimertinib in patients with epidermal growth factor receptor mutation non‐small cell lung cancer and brain metastases: A positron emission tomography and …
S Ekman, Z Cselényi, A Varrone, A Jucaite, H Martin, M Schou, ...
Clinical and Translational Science 16 (6), 955-965, 2023
10*2023
Quantification of human brain PDE4 occupancy by GSK356278: A [11C](R)-rolipram PET study
J van der Aart, C Salinas, R Dimber, S Pampols-Maso, AA Weekes, ...
Journal of Cerebral Blood Flow & Metabolism 38 (11), 2033-2040, 2018
62018
In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT1(A/B/D) receptor antagonist, GSK588045, using Positron Emission Tomography
RA Comley, J van der Aart, B Gulyás, M Garnier, L Iavarone, C Halldin, ...
Neuropharmacology 92, 44–48, 2015
52015
Safety and pharmacokinetics of HTL0018318, a novel M1 receptor agonist, given in combination with donepezil at steady state: a randomized trial in healthy elderly subjects
C Bakker, J van der Aart, G Labots, J Liptrot, DM Cross, ES Klaassen, ...
Drugs in R&D 21 (3), 295-304, 2021
42021
Human Dosimetry of the N-Methyl-d-Aspartate Receptor Ligand 11C-GMOM
J Van der Aart, T Van der Doef, P Horstman, MC Huisman, RC Schuit, ...
Journal of Nuclear Medicine: Society of Nuclear Medicine 58 (8), 1330-1333, 2017
22017
Amphetamine Induced Psychomotor Improvement in Relation to Striatal Dopamine Release in Healthy Subjects
J van der Aart, H van Gorsel, M de Kam, M Yaqub, AA Lammertsma, ...
Journal of Cerebral Blood Flow & Metabolism 36, 735-736, 2016
12016
The role of clinical imaging in oncology drug development: progress and new challenges
PS Murphy, P Galette, J van der Aart, RL Janiczek, N Patel, AP Brown
The British Journal of Radiology 96 (1150), 20211126, 2023
2023
TP53 loss with whole genome doubling mediates heterogeneous intra-patient therapy response in EGFR-driven lung adenocarcinoma: A TRACERx study
S Hobor, MA Bakir, M Skrzypski, AM Frankell, B Bakker, TB Watkins, ...
Cancer Research 82 (12_Supplement), 6217-6217, 2022
2022
Positron Emission Tomography of Novel Radiotracers for the Central Nervous System: Radiation Dosimetry and Translational Imaging Studies
J Van der Aart
Amsterdam UMC, location VUmc, 2019
2019
Effects of Occipital Nerve Stimulation on Cerebral Blood Flow in Patients with Medically Intractable Chronic Cluster Headache
IF De Coo, J van der Aart, LA Wilbrink, PG Doesborg, H Abrabi, M Yaqub, ...
CEPHALALGIA 37, 124-124, 2017
2017
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