Crystal structure of photosystem II from Synechococcus elongatus at 3.8 Å resolution A Zouni, HT Witt, J Kern, P Fromme, N Krauss, W Saenger, P Orth Nature 409 (6821), 739-743, 2001 | 2557 | 2001 |
Structural basis of gene regulation by the tetracycline inducible Tet repressor–operator system P Orth, D Schnappinger, W Hillen, W Saenger, W Hinrichs Nature structural biology 7 (3), 215-219, 2000 | 643 | 2000 |
The tetracycline repressor—a paradigm for a biological switch W Saenger, P Orth, C Kisker, W Hillen, W Hinrichs Angewandte Chemie International Edition 39 (12), 2042-2052, 2000 | 174 | 2000 |
Conformational changes of the Tet repressor induced by tetracycline trapping P Orth, F Cordes, D Schnappinger, W Hillen, W Saenger, W Hinrichs Journal of molecular biology 279 (2), 439-447, 1998 | 172 | 1998 |
Excited-state dynamics in photosystem II: Insights from the x-ray crystal structure S Vasil'ev, P Orth, A Zouni, TG Owens, D Bruce Proceedings of the National Academy of Sciences 98 (15), 8602-8607, 2001 | 164 | 2001 |
Discovery of the 3-imino-1, 2, 4-thiadiazinane 1, 1-dioxide derivative verubecestat (MK-8931)–a β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment … JD Scott, SW Li, APJ Brunskill, X Chen, K Cox, JN Cumming, M Forman, ... Journal of medicinal chemistry 59 (23), 10435-10450, 2016 | 157 | 2016 |
Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography P Orth, L Xiao, LD Hernandez, P Reichert, PR Sheth, M Beaumont, ... Journal of biological chemistry 289 (26), 18008-18021, 2014 | 149 | 2014 |
Discovery of an orally available, brain penetrant BACE1 inhibitor that affords robust CNS Aβ reduction AW Stamford, JD Scott, SW Li, S Babu, D Tadesse, R Hunter, Y Wu, ... ACS medicinal chemistry letters 3 (11), 897-902, 2012 | 106 | 2012 |
Engineered anti-IL-23 antibodies LG Presta, BM Beyer, RN Ingram, P Orth, YH Liu US Patent 7,807,160, 2010 | 104 | 2010 |
Crystal structure of the catalytic domain of human ADAM33 P Orth, P Reichert, W Wang, WW Prosise, T Yarosh-Tomaine, ... Journal of molecular biology 335 (1), 129-137, 2004 | 102 | 2004 |
Photosystem II single crystals studied by EPR spectroscopy at 94 GHz: The tyrosine radical Y W Hofbauer, A Zouni, R Bittl, J Kern, P Orth, F Lendzian, P Fromme, ... Proceedings of the National Academy of Sciences 98 (12), 6623-6628, 2001 | 95 | 2001 |
Tetracycline-Chelated Mg2+ Ion Initiates Helix Unwinding in Tet Repressor Induction, P Orth, W Saenger, W Hinrichs Biochemistry 38 (1), 191-198, 1999 | 91 | 1999 |
Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity H Lan, CC Cheng, TJ Kowalski, L Pang, L Shan, CC Chuang, J Jackson, ... Journal of lipid research 52 (4), 646-656, 2011 | 89 | 2011 |
Specific binding of divalent metal ions to tetracycline and to the Tet repressor/tetracycline complex GJ Palm, T Lederer, P Orth, W Saenger, M Takahashi, W Hillen, ... JBIC Journal of Biological Inorganic Chemistry 13, 1097-1110, 2008 | 81 | 2008 |
Crystal structure of ω transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 Å resolution K Murayama, P Orth, AB de la Hoz, JC Alonso, W Saenger Journal of molecular biology 314 (4), 789-796, 2001 | 81 | 2001 |
A series of novel, highly potent, and orally bioavailable next-generation tricyclic peptide PCSK9 inhibitors TJ Tucker, MW Embrey, C Alleyne, RP Amin, A Bass, B Bhatt, E Bianchi, ... Journal of Medicinal Chemistry 64 (22), 16770-16800, 2021 | 72 | 2021 |
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation M Mandal, Z Zhu, JN Cumming, X Liu, C Strickland, RD Mazzola, ... Journal of medicinal chemistry 55 (21), 9331-9345, 2012 | 70 | 2012 |
Design, synthesis, and X-ray crystallographic analysis of a novel class of HIV-1 protease inhibitors AK Ganguly, SS Alluri, D Caroccia, D Biswas, CH Wang, E Kang, Y Zhang, ... Journal of medicinal chemistry 54 (20), 7176-7183, 2011 | 70 | 2011 |
Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody BM Beyer, R Ingram, L Ramanathan, P Reichert, HV Le, V Madison, ... Journal of molecular biology 382 (4), 942-955, 2008 | 69 | 2008 |
Crystal structure of the tet repressor in complex with a novel tetracycline, 9-(N, N-dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline P Orth, D Schnappinger, PE Sum, GA Ellestad, W Hillen, W Saenger, ... Journal of molecular biology 285 (2), 455-461, 1999 | 67 | 1999 |