| An asymmetric synthesis of L-694,458, a human leukocyte elastase inhibitor, via novel enzyme resolution of β-lactam esters RJ Cvetovich, M Chartrain, FW Hartner, C Roberge, JS Amato, ... The Journal of organic chemistry 61 (19), 6575-6580, 1996 | 94 | 1996 |
| Microbial method MM Chartrain, SST Chen, GM Garrity, B Heimbuch, C Roberge, A Shafiee US Patent 5,491,077, 1996 | 74 | 1996 |
| Chiral bio-resolution of racemic indene oxide by fungal epoxide hydrolases J Zhang, J Reddy, C Roberge, C Senanayake, R Greasham, M Chartrain Journal of fermentation and bioengineering 80 (3), 244-246, 1995 | 62 | 1995 |
| Preparation and application of cross-linked aggregates of chloroperoxidase with enhanced hydrogen peroxide tolerance C Roberge, D Amos, D Pollard, P Devine Journal of Molecular Catalysis B: Enzymatic 56 (1), 41-45, 2009 | 53 | 2009 |
| Practical chemoenzymatic synthesis of a 3-pyridylethanolamino β3 adrenergic receptor agonist JYL Chung, GJ Ho, M Chartrain, C Roberge, D Zhao, J Leazer, R Farr, ... Tetrahedron Letters 40 (37), 6739-6743, 1999 | 46 | 1999 |
| Synthesis of optically active cyanohydrins from aromatic ketones: evidence of an increased substrate range and inverted stereoselectivity for the hydroxynitrile lyase from … C Roberge, F Fleitz, D Pollard, P Devine Tetrahedron: Asymmetry 18 (2), 208-214, 2007 | 37 | 2007 |
| Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex EM Bassan, CA Baxter, GL Beutner, KM Emerson, FJ Fleitz, S Johnson, ... Organic Process Research & Development 16 (1), 87-95, 2012 | 36 | 2012 |
| Asymmetric bioreduction of (2-(4-nitro-phenyl)-N-(2-oxo-2-pyridin-3-yl-ethyl)-acetamide) to its corresponding (R) alcohol [(R)-N-(2-hydroxy-2-pyridin-3-yl-ethyl)-2-(4-nitro … M Chartrain, C Roberge, J Chung, J McNamara, D Zhao, R Olewinski, ... Enzyme and microbial technology 25 (6), 489-496, 1999 | 32 | 1999 |
| Asymmetric synthesis of cyanohydrin derived from pyridine aldehyde with cross-linked aggregates of hydroxynitrile lyases C Roberge, F Fleitz, D Pollard, P Devine Tetrahedron letters 48 (8), 1473-1477, 2007 | 31 | 2007 |
| Bioconversion of indene to trans-2S, 1S-bromoindanol and 1S, 2R-indene oxide by a bromoperoxidase/dehydrogenase preparation from Curvularia protuberata MF5400 J Zhang, C Roberge, J Reddy, N Connors, M Chartrain, B Buckland, ... Enzyme and microbial technology 24 (1-2), 86-95, 1999 | 30 | 1999 |
| Asymmetric bioreduction of a keto ester to its corresponding (S)-hydroxy ester by Microbacterium sp. MB 5614 C Roberge, A King, V Pecore, R Greasham, M Chartrain Journal of fermentation and bioengineering 81 (6), 530-533, 1996 | 21 | 1996 |
| The highly stereospecific enzyme catalysed transamination of 4-fluorophenylglyoxylic acid to 4-(S)-fluorophenylglycine M Cameron, D Cohen, IF Cottrell, DJ Kennedy, C Roberge, M Chartrain Journal of Molecular Catalysis B: Enzymatic 14 (1-3), 1-5, 2001 | 20 | 2001 |
| Asymmetric Kulinkovich hydroxycyclopropanation of alkenes mediated by titanium (IV) TADDOLate complexes M Iskryk, M Barysevich, M Ošeka, J Adamson, D Kananovich Synthesis 51 (09), 1935-1948, 2019 | 17 | 2019 |
| Asymmetric biosynthesis of key aromatic intermediates in the synthesis of an endothelin receptor antagonist B Krulewicz, D Tschaen, P Devine, SS Lee, C Roberge, R Greasham, ... Biocatalysis and Biotransformation 19 (4), 267-279, 2001 | 17 | 2001 |
| Process development for the production of the (S)-acid precursor of a novel elastase inhibitor (L-694,458) through the lipase-catalyzed kinetic resolution of a β-lactam benzyl … C Roberge, RJ Cvetovich, JS Amato, V Pecore, FW Hartner, R Greasham, ... Journal of fermentation and bioengineering 83 (1), 48-53, 1997 | 12 | 1997 |
| Appl. WO 99, 07, 695 (Cl. CO7D 401/00)(1999) DR Sidler, RD Larson, M Chartrain, N Lkemato, CM Roberge Chem. Abstr 130, 182478v, 1999 | 10 | 1999 |
| Process for N-Boc-N-(R)-2 (3-pyridyl)-2-hydroxy-ethyl)-N-2 (4-aminophenyl) ethyl amine and 2-(4-aminophenyl)-N-2-(2 (R)-hydroxy-2-phyridin-S-yl-ethyl) acetamide MM Chartrain, C Roberge, JYL Chung, D Zhao US Patent 5,792,871, 1998 | 10 | 1998 |
| Enzymatic hydrolysis of 3, 3-diethyl-4-[(4-carboxy) phenoxy]-2-azetidinone esters MM Chartrain, R Cvetovich, C Roberge US Patent 5,523,233, 1996 | 6 | 1996 |
| Alpha 1a adrenergic receptor antagonist DR Sidler, RD Larsen, M Chartrain, N Ikemoto, CM Roberg, CS Taylor, ... PCT Int Appl WO 99, 07695, 1999 | 5 | 1999 |
| N-(R)-(2-hydroxy-2-pyridine-3-yl-ethyl)-2-(4-nitro-phenyl)-acetamide MM Chartrain, JYL Chung, C Roberge US Patent 5,846,791, 1998 | 5 | 1998 |
