| The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers NS Baranova, E Nilebäck, FM Haller, DC Briggs, S Svedhem, AJ Day, ... Journal of Biological Chemistry 286 (29), 25675-25686, 2011 | 162 | 2011 |
| The angiogenic inhibitor long pentraxin PTX3 forms an asymmetric octamer with two binding sites for FGF2 A Inforzato, C Baldock, TA Jowitt, DF Holmes, R Lindstedt, M Marcellini, ... Journal of Biological Chemistry 285 (23), 17681-17692, 2010 | 124 | 2010 |
| Structure of the food-poisoning Clostridium perfringens enterotoxin reveals similarity to the aerolysin-like pore-forming toxins. DC Briggs, CE Naylor, JG Smedley III, N Lukoyanova, S Robertson, ... Journal of Molecular Biology, 2011 | 98 | 2011 |
| Structural basis of laminin binding to the LARGE glycans on dystroglycan DC Briggs, T Yoshida-Moriguchi, T Zheng, D Venzke, ME Anderson, ... Nature chemical biology 12 (10), 810-814, 2016 | 95 | 2016 |
| Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding B Boëda, DC Briggs, T Higgins, BK Garvalov, AJ Fadden, NQ McDonald, ... Molecular cell 28 (6), 1071-1082, 2007 | 87 | 2007 |
| Incorporation of pentraxin 3 into hyaluronan matrices is tightly regulated and promotes matrix cross-linking NS Baranova, A Inforzato, DC Briggs, V Tilakaratna, JJ Enghild, D Thakar, ... Journal of Biological Chemistry 289 (44), 30481-30498, 2014 | 77 | 2014 |
| Inter-α-inhibitor impairs TSG-6-induced hyaluronan cross-linking NS Baranova, SJ Foulcer, DC Briggs, V Tilakaratna, JJ Enghild, ... Journal of Biological Chemistry 288 (41), 29642-29653, 2013 | 76 | 2013 |
| Structural relationships and cellular tropism of staphylococcal superantigen-like proteins AM Al-Shangiti, CE Naylor, SP Nair, DC Briggs, B Henderson, BM Chain Infection and immunity 72 (7), 4261-4270, 2004 | 66 | 2004 |
| Metal ion-dependent heavy chain transfer activity of TSG-6 mediates assembly of the cumulus-oocyte matrix DC Briggs, HL Birchenough, T Ali, MS Rugg, JP Waltho, E Ievoli, TA Jowitt, ... Journal of Biological Chemistry 290 (48), 28708-28723, 2015 | 58 | 2015 |
| A refined model for the TSG-6 link module in complex with hyaluronan use of defined oligosaccharides to probe structure and function VA Higman, DC Briggs, DJ Mahoney, CD Blundell, BM Sattelle, DP Dyer, ... Journal of Biological Chemistry 289 (9), 5619-5634, 2014 | 58 | 2014 |
| Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation MF Debets, OY Tastan, SP Wisnovsky, SA Malaker, N Angelis, ... Proceedings of the National Academy of Sciences 117 (41), 25293-25301, 2020 | 53 | 2020 |
| Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases GC Fox, M Shafiq, DC Briggs, PP Knowles, M Collister, MJ Didmon, ... Nature 447 (7143), 487-492, 2007 | 48 | 2007 |
| Molecular recognition of the Tes LIM2–3 domains by the actin-related protein Arp7A B Boëda, PP Knowles, DC Briggs, J Murray-Rust, E Soriano, BK Garvalov, ... Journal of Biological Chemistry 286 (13), 11543-11554, 2011 | 40 | 2011 |
| Structural basis for the initiation of glycosaminoglycan biosynthesis by human xylosyltransferase 1 DC Briggs, E Hohenester Structure 26 (6), 801-809. e3, 2018 | 38 | 2018 |
| Homodimerization of the lymph vessel endothelial receptor LYVE-1 through a redox-labile disulfide is critical for hyaluronan binding in lymphatic endothelium S Banerji, W Lawrance, C Metcalfe, DC Briggs, A Yamauchi, O Dushek, ... Journal of Biological Chemistry 291 (48), 25004-25018, 2016 | 36 | 2016 |
| Clostridium absonum α-toxin: New insights into clostridial phospholipase C substrate binding and specificity GC Clark, DC Briggs, T Karasawa, X Wang, AR Cole, T Maegawa, ... Journal of molecular biology 333 (4), 759-769, 2003 | 35 | 2003 |
| Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1–4 P Paracuellos, DC Briggs, F Carafoli, T Lončar, E Hohenester Structure 23 (11), 2133-2142, 2015 | 25 | 2015 |
| Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation M Jones, F Beuron, A Borg, A Nans, CP Earl, DC Briggs, AP Snijders, ... Nature communications 11 (1), 1120, 2020 | 24 | 2020 |
| Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation DC Briggs, AWW Langford-Smith, HL Birchenough, TA Jowitt, CM Kielty, ... Journal of Biological Chemistry 295 (16), 5278-5291, 2020 | 21 | 2020 |
| Bioisosteric Discovery of NPA101. 3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology M Moccia, B Frett, L Zhang, NR Lakkaniga, DC Briggs, R Chauhan, ... Journal of Medicinal Chemistry 63 (9), 4506-4516, 2020 | 21 | 2020 |
Anthony J. DayProfessor of Biochemistry, University of Manchester, UKVerified email at manchester.ac.uk
