| Membrane transporters in drug development Nature reviews Drug discovery 9 (3), 215-236, 2010 | 3484 | 2010 |
| Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating … P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ... Archives of toxicology 87, 1315-1530, 2013 | 1390 | 2013 |
| Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance JB Houston Biochemical pharmacology 47 (9), 1469-1479, 1994 | 1075 | 1994 |
| Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism … NJ Hewitt, MJ Gómez Lechón, JB Houston, D Hallifax, HS Brown, ... Drug metabolism reviews 39 (1), 159-234, 2007 | 843 | 2007 |
| The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions RS Obach, RL Walsky, K Venkatakrishnan, EA Gaman, JB Houston, ... Journal of Pharmacology and Experimental Therapeutics 316 (1), 336-348, 2006 | 499 | 2006 |
| Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human micro-somal protein and hepatocellularity … ZE Barter, MK Bayliss, PH Beaune, AR Boobis, DJ Carlile, RJ Edwards, ... Current drug metabolism 8 (1), 33-45, 2007 | 491 | 2007 |
| In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model JB Houston, KE Kenworthy Drug Metabolism and Disposition 28 (3), 246-254, 2000 | 480 | 2000 |
| CYP3A4 drug interactions: correlation of 10 in vitro probe substrates Kenworthy, Bloomer, Houston British journal of clinical pharmacology 48 (5), 716-727, 1999 | 429 | 1999 |
| Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices J Brian Houston, DJ Carlile Drug metabolism reviews 29 (4), 891-922, 1997 | 390 | 1997 |
| Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by … V Uchaipichat, PI Mackenzie, XH Guo, D Gardner-Stephen, A Galetin, ... Drug Metabolism and Disposition 32 (4), 413-423, 2004 | 379 | 2004 |
| Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data M Gertz, A Harrison, JB Houston, A Galetin Drug Metabolism and Disposition 38 (7), 1147-1158, 2010 | 334 | 2010 |
| Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus GT Tucker, JB Houston, SM Huang Pharmaceutical research 18 (8), 1071, 2001 | 323 | 2001 |
| Database analyses for the prediction of in vivo drug–drug interactions from in vitro data K Ito, HS Brown, JB Houston British journal of clinical pharmacology 57 (4), 473-486, 2004 | 321 | 2004 |
| Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches K Ito, JB Houston Pharmaceutical research 22, 103-112, 2005 | 298 | 2005 |
| Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data HM Jones, HA Barton, Y Lai, Y Bi, E Kimoto, S Kempshall, SC Tate, ... Drug Metabolism and Disposition 40 (5), 1007-1017, 2012 | 263 | 2012 |
| In vitro–in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises JO Miners, KM Knights, JB Houston, PI Mackenzie Biochemical pharmacology 71 (11), 1531-1539, 2006 | 262 | 2006 |
| Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes K Ito, JB Houston Pharmaceutical research 21, 785-792, 2004 | 255 | 2004 |
| Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance HS Brown, M Griffin, JB Houston Drug metabolism and disposition 35 (2), 293-301, 2007 | 249 | 2007 |
| Isoform selectivity and kinetics of morphine 3-and 6-glucuronidation by human UDP-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7 AN Stone, PI Mackenzie, A Galetin, JB Houston, JO Miners Drug Metabolism and Disposition 31 (9), 1086-1089, 2003 | 244 | 2003 |
| Structure: action relationships among some desacetoxy analogues of pancuronium and vecuronium in the anesthetized cat. WC Bowman, IW Rodger, J Houston, RJ Marshall, I McIndewar Anesthesiology 69 (1), 57-62, 1988 | 226 | 1988 |
