| Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography M Adachi, T Ohhara, K Kurihara, T Tamada, E Honjo, N Okazaki, S Arai, ... Proceedings of the National Academy of Sciences 106 (12), 4641-4646, 2009 | 160 | 2009 |
| High-Affinity Inhibition of a Family of Plasmodium falciparum Proteases by a Designed Adaptive Inhibitor A Nezami, T Kimura, K Hidaka, A Kiso, J Liu, Y Kiso, DE Goldberg, ... Biochemistry 42 (28), 8459-8464, 2003 | 146 | 2003 |
| Design and synthesis of highly active Alzheimer’s β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability T Kimura, D Shuto, Y Hamada, N Igawa, S Kasai, P Liu, K Hidaka, ... Bioorganic & medicinal chemistry letters 15 (1), 211-215, 2005 | 138 | 2005 |
| KMI-008, a novel β-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides D Shuto, S Kasai, T Kimura, P Liu, K Hidaka, T Hamada, S Shibakawa, ... Bioorganic & medicinal chemistry letters 13 (24), 4273-4276, 2003 | 108 | 2003 |
| Design and synthesis of potent β-secretase (BACE1) inhibitors with P1′ carboxylic acid bioisosteres T Kimura, Y Hamada, M Stochaj, H Ikari, A Nagamine, H Abdel-Rahman, ... Bioorganic & medicinal chemistry letters 16 (9), 2380-2386, 2006 | 93 | 2006 |
| KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine T Kimura, D Shuto, S Kasai, P Liu, K Hidaka, T Hamada, Y Hayashi, ... Bioorganic & medicinal chemistry letters 14 (6), 1527-1531, 2004 | 93 | 2004 |
| Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor JC Clemente, L Govindasamy, A Madabushi, SZ Fisher, RE Moose, ... Acta Crystallographica Section D: Biological Crystallography 62 (3), 246-252, 2006 | 75 | 2006 |
| New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors T Regnier, D Sarma, K Hidaka, U Bacha, E Freire, Y Hayashi, Y Kiso Bioorganic & medicinal chemistry letters 19 (10), 2722-2727, 2009 | 64 | 2009 |
| How much binding affinity can be gained by filling a cavity? Y Kawasaki, EE Chufan, V Lafont, K Hidaka, Y Kiso, L Mario Amzel, ... Chemical biology & drug design 75 (2), 143-151, 2010 | 62 | 2010 |
| β-Secretase inhibitors: Modification at the P4 position and improvement of inhibitory activity in cultured cells Y Hamada, N Igawa, H Ikari, Z Ziora, JT Nguyen, A Yamani, K Hidaka, ... Bioorganic & medicinal chemistry letters 16 (16), 4354-4359, 2006 | 61 | 2006 |
| Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases HM Abdel-Rahman, T Kimura, K Hidaka, A Kiso, A Nezami, E Freire, ... Walter de Gruyter 385 (11), 1035-1039, 2004 | 54 | 2004 |
| Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum P Bhaumik, Y Horimoto, H Xiao, T Miura, K Hidaka, Y Kiso, A Wlodawer, ... Journal of structural biology 175 (1), 73-84, 2011 | 53 | 2011 |
| Novel non-peptidic and small-sized BACE1 inhibitors Y Hamada, H Ohta, N Miyamoto, R Yamaguchi, A Yamani, K Hidaka, ... Bioorganic & medicinal chemistry letters 18 (5), 1654-1658, 2008 | 50 | 2008 |
| BACE1 inhibitors: Optimization by replacing the P1′ residue with non-acidic moiety Y Hamada, H Abdel-Rahman, A Yamani, JT Nguyen, M Stochaj, K Hidaka, ... Bioorganic & medicinal chemistry letters 18 (5), 1649-1653, 2008 | 49 | 2008 |
| Search for substrate‐based inhibitors fitting the S2′ space of malarial aspartic protease plasmepsin II A Kiso, K Hidaka, T Kimura, Y Hayashi, A Nezami, E Freire, Y Kiso Journal of Peptide Science: An Official Publication of the European Peptide …, 2004 | 48 | 2004 |
| Analysis of Amide Bond Formation with an α-Hydroxy-β-amino acid derivative, 3-amino-2-hydroxy-4-phenylbutanoic Acid, as an Acyl Component: Byproduction of Homobislactone Y Hayashi, Y Kinoshita, K Hidaka, A Kiso, H Uchibori, T Kimura, Y Kiso The Journal of Organic Chemistry 66 (16), 5537-5544, 2001 | 45 | 2001 |
| Anti-microtubule ‘plinabulin’chemical probe KPU-244-B3 labeled both α-and β-tubulin Y Yamazaki, M Sumikura, K Hidaka, H Yasui, Y Kiso, F Yakushiji, ... Bioorganic & medicinal chemistry 18 (9), 3169-3174, 2010 | 44 | 2010 |
| Combination of Non-natural d-Amino Acid Derivatives and Allophenylnorstatine−Dimethylthioproline Scaffold in HIV Protease Inhibitors Have High Efficacy in … S Nakatani, K Hidaka, E Ami, K Nakahara, A Sato, JT Nguyen, Y Hamada, ... Journal of medicinal chemistry 51 (10), 2992-3004, 2008 | 43 | 2008 |
| Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin K Hidaka, T Kimura, AJ Ruben, T Uemura, M Kamiya, A Kiso, T Okamoto, ... Bioorganic & medicinal chemistry 16 (23), 10049-10060, 2008 | 41 | 2008 |
| X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors RHP Law, G Wu, EWW Leung, K Hidaka, AJ Quek, TT Caradoc-Davies, ... Blood advances 1 (12), 766-771, 2017 | 36 | 2017 |
Ernesto FreireHenry Walters Professor, Johns Hopkins UniversityVerified email at jhu.edu
