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Daniel Rakiec
Daniel Rakiec
Novartis Institutes for Biomedical Research
Verified email at novartis.com
Title
Cited by
Cited by
Year
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide)
M Korpal, JM Korn, X Gao, DP Rakiec, DA Ruddy, S Doshi, J Yuan, ...
Cancer discovery 3 (9), 1030-1043, 2013
6002013
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
HC Bhang, DA Ruddy, V Krishnamurthy Radhakrishna, JX Caushi, ...
Nature medicine 21 (5), 440-448, 2015
5192015
Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma
R Rahal, M Frick, R Romero, JM Korn, R Kridel, F Chun Chan, B Meissner, ...
Nature medicine 20 (1), 87-92, 2014
3962014
CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions
DM Munoz, PJ Cassiani, L Li, E Billy, JM Korn, MD Jones, J Golji, ...
Cancer discovery 6 (8), 900-913, 2016
3772016
Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss
H Liu, J Golji, LK Brodeur, FS Chung, JT Chen, RS deBeaumont, ...
Nature medicine 25 (1), 95-102, 2019
2512019
Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer
S Raoof, IJ Mulford, H Frisco-Cabanos, V Nangia, D Timonina, E Labrot, ...
Oncogene 38 (37), 6399-6413, 2019
1782019
A chemical genetics approach for the functional assessment of novel cancer genes
Q Zhou, A Derti, D Ruddy, D Rakiec, I Kao, M Lira, V Gibaja, HM Chan, ...
Cancer research 75 (10), 1949-1958, 2015
1302015
FGFR-mediated reactivation of MAPK signaling attenuates antitumor effects of imatinib in gastrointestinal stromal tumors
F Li, H Huynh, X Li, DA Ruddy, Y Wang, R Ong, P Chow, S Qiu, A Tam, ...
Cancer discovery 5 (4), 438-451, 2015
1052015
CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development
GH Mochida, VS Ganesh, MI De Michelena, H Dias, KD Atabay, ...
Nature genetics 44 (11), 1260-1264, 2012
1042012
A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts
GH Mochida, VS Ganesh, JM Felie, D Gleason, RS Hill, KR Clapham, ...
The American Journal of Human Genetics 87 (6), 882-889, 2010
1042010
Inhibition of casein kinase 1 alpha prevents acquired drug resistance to Erlotinib in EGFR-mutant non–small cell lung cancer
AB Lantermann, D Chen, K McCutcheon, G Hoffman, E Frias, D Ruddy, ...
Cancer Research 75 (22), 4937-4948, 2015
602015
Combined ALK and MDM2 inhibition increases antitumor activity and overcomes resistance in human ALK mutant neuroblastoma cell lines and xenograft models
HQ Wang, E Halilovic, X Li, J Liang, Y Cao, DP Rakiec, DA Ruddy, S Jeay, ...
Elife 6, e17137, 2017
562017
Hyperactivation of MAPK signaling is deleterious to RAS/RAF-mutant melanoma
GP Leung, T Feng, FD Sigoillot, FC Geyer, MD Shirley, DA Ruddy, ...
Molecular Cancer Research 17 (1), 199-211, 2019
552019
The lineage determining factor GRHL2 collaborates with FOXA1 to establish a targetable pathway in endocrine therapy-resistant breast cancer
KJ Cocce, JS Jasper, TK Desautels, L Everett, S Wardell, T Westerling, ...
Cell reports 29 (4), 889-903. e10, 2019
512019
An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide) Cancer Discov. 2013; 3: 1030–1043. doi: 10.1158/2159-8290
M Korpal, JM Korn, X Gao, DP Rakiec, DA Ruddy, S Doshi, J Yuan, ...
Cd-13-0142.[Abstract][CrossRef][Google Scholar], 0
42
BRAF-inhibitor associated MEK mutations increase RAF-dependent and-independent enzymatic activity
CM Emery, KA Monaco, P Wang, M Balak, A Freeman, J Meltzer, ...
Molecular Cancer Research 15 (10), 1431-1444, 2017
242017
A proof of concept for biomarker-guided targeted therapy against ovarian cancer based on patient-derived tumor xenografts
AC Palmer, D Plana, H Gao, JM Korn, G Yang, J Green, X Zhang, ...
Cancer research 80 (19), 4278-4287, 2020
142020
In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling
Z Jagani, G Chenail, K Xiang, G Bushold, HEC Bhang, A Li, GN Elliott, ...
Biorxiv, 812628, 2019
102019
RAF-mutant melanomas differentially depend on ERK2 over ERK1 to support aberrant MAPK pathway activation and cell proliferation
MS Crowe, T Zavorotinskaya, CF Voliva, MD Shirley, Y Wang, DA Ruddy, ...
Molecular Cancer Research 19 (6), 1063-1075, 2021
32021
Distinct Transcriptional Programming Drive Response to MAPK Inhibition in BRAFV600-Mutant Melanoma Patient-Derived Xenografts
T Feng, J Golji, A Li, X Zhang, DA Ruddy, DP Rakiec, FC Geyer, J Gu, ...
Molecular Cancer Therapeutics 18 (12), 2421-2432, 2019
32019
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