Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers AR Parikh, I Leshchiner, L Elagina, L Goyal, C Levovitz, G Siravegna, ... Nature medicine 25 (9), 1415-1421, 2019 | 417 | 2019 |
Parallel genomic alterations of antigen and payload targets mediate polyclonal acquired clinical resistance to sacituzumab govitecan in triple-negative breast cancer JT Coates, S Sun, I Leshchiner, N Thimmiah, EE Martin, D McLoughlin, ... Cancer discovery 11 (10), 2436-2445, 2021 | 88 | 2021 |
Parallel genomic alterations of antigen and payload targets mediate polyclonal acquired clinical resistance to sacituzumab govitecan in triple-negative breast cancer. Cancer … JT Coates, S Sun, I Leshchiner, N Thimmiah, EE Martin, D McLoughlin, ... DOI: https://doi. org/10.1158/2159-8290. CD-21-0702, 2436-2445, 0 | 21 | |
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations A Varkaris, F Fece de la Cruz, EE Martin, BL Norden, N Chevalier, ... Cancer Discovery 14 (2), 227-239, 2024 | 10 | 2024 |
Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers AR Parikh, I Leshchiner, L Elagina, L Goyal, C Levovitz, G Siravegna, ... Nature medicine 25 (12), 1949-1949, 2019 | 3 | 2019 |
TuFEst: a sensitive and cost-effective pan-cancer detection approach with accurate tumor fraction estimation Z Lin, C Stewart, EE Martin, BP Danysh, RA Jacobs, K Slowik, L Lawton, ... Cancer Research 82 (12_Supplement), 5162-5162, 2022 | 2 | 2022 |
Convergence of resistance patterns in breast cancer after multiple lines of treatment through analysis of rapid autopsy samples I Leshchiner, EE Martin, CT Chen, E Leshchiner, T Zhang, C Pinto, F Utro, ... Cancer Research 81 (13_Supplement), 37-37, 2021 | 1 | 2021 |
Abstract GS03-10: Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations A Varkaris, FF Cruz, E Martin, B Nordern, N Chevalier, I Leshchiner, ... Cancer Research 84 (9_Supplement), GS03-10-GS03-10, 2024 | | 2024 |
Abstract LB449: Strategies to overcome resistance to PI3Kalpha-selective inhibitors mediated by acquired alterations in the PI3K/AKT pathway FF Cruz, A Varkaris, EE Martin, BL Norden, N Chevalier, AM Kehlmann, ... Cancer Research 84 (7_Supplement), LB449-LB449, 2024 | | 2024 |
Phylogenetic reconstruction across 303 metastatic tumor samples using Ultima whole-genome sequencing dramatically increases subclonal resolution J Hess, E Martin, I Soifer, H Benjamin, M Miller, C Cibulskis, BP Danysh, ... Cancer Research 83 (7_Supplement), 213-213, 2023 | | 2023 |
Chromatin modifier alterations confer resistance to endocrine deprivation and CDK4/6 inhibitors in ER+ breast cancer and drive convergent evolution in patient autopsy lesions E Leshchiner, I Leshchiner, EE Martin, CT Chen, T Zhang, C Pinto, ... Cancer Research 82 (12_Supplement), 1789-1789, 2022 | | 2022 |
Determining patterns of cancer drug resistance from autopsy patients EE Martin Massachusetts Institute of Technology, 2020 | | 2020 |
Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers (vol 25, pg 1415, 2019) AR Parikh, I Leshchiner, L Elagina, L Goyal, C Levovitz, G Siravegna, ... NATURE MEDICINE 25 (12), 1949-1949, 2019 | | 2019 |