CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences Y Lin, TJ Cradick, MT Brown, H Deshmukh, P Ranjan, N Sarode, BM Wile, ... Nucleic acids research 42 (11), 7473-7485, 2014 | 734 | 2014 |
A self-deleting AAV-CRISPR system for in vivo genome editing A Li, CM Lee, AE Hurley, KE Jarrett, M De Giorgi, W Lu, KS Balderrama, ... Molecular Therapy-Methods & Clinical Development 12, 111-122, 2019 | 126 | 2019 |
Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets H Zhu, L Zhang, S Tong, CM Lee, H Deshmukh, G Bao Nature biomedical engineering 3 (2), 126-136, 2019 | 119 | 2019 |
Trans-spliced Cas9 allows cleavage of HBB and CCR5 genes in human cells using compact expression cassettes EJ Fine, CM Appleton, DE White, MT Brown, H Deshmukh, ML Kemp, ... Scientific reports 5 (1), 10777, 2015 | 72 | 2015 |
Efficient fdCas9 synthetic endonuclease with improved specificity for precise genome engineering M Aouida, A Eid, Z Ali, T Cradick, C Lee, H Deshmukh, A Atef, ... PloS one 10 (7), e0133373, 2015 | 66 | 2015 |
Gold nanoparticles electroporation enhanced polyplex delivery to mammalian cells S Huang, H Deshmukh, KK Rajagopalan, S Wang Electrophoresis 35 (12-13), 1837-1845, 2014 | 30 | 2014 |
Comprehensive analysis and accurate quantification of unintended large gene modifications induced by CRISPR-Cas9 gene editing SH Park, M Cao, Y Pan, TH Davis, L Saxena, H Deshmukh, Y Fu, ... Science Advances 8 (42), eabo7676, 2022 | 29 | 2022 |
Therapeutic CRISPR/Cas9 genome editing for treating sickle cell disease SH Park, CM Lee, H Deshmukh, G Bao Blood 128 (22), 4703, 2016 | 29 | 2016 |
A Self-Deleting AAV-CRISPR System for A Li, CM Lee, AE Hurley, KE Jarrett, M De Giorgi, W Lu, KS Balderrama, ... Vivo, 2018 | 10 | 2018 |
Design and validation of CRISPR/Cas9 systems for targeted gene modification in induced pluripotent stem cells CM Lee, H Zhu, TH Davis, H Deshmukh, G Bao In Vitro Mutagenesis, 3-21, 2017 | 9 | 2017 |
Pitfalls in single clone CRISPR-Cas9 mutagenesis to fine-map regulatory intervals R Tian, Y Pan, THA Etheridge, H Deshmukh, D Gulick, G Gibson, G Bao, ... Genes 11 (5), 504, 2020 | 6 | 2020 |
Visualization of RNA virus infection in a marine protist with a universal biomarker SR Coy, B Utama, JW Spurlin, JG Kim, H Deshmukh, P Lwigale, ... Scientific Reports 13 (1), 5813, 2023 | 5 | 2023 |
131. Chromatin-Dependent Loci Accessibility Affects CRISPR-Cas9 Targeting Efficiency CM Lee, TH Davis, H Deshmukh, G Bao Molecular Therapy 24, S54, 2016 | 1 | 2016 |
Enhance the Transfection of Mammalian Cells using Polyethylenimine (PEI) Coated Gold Nanoparticles HA Deshmukh Louisiana Tech University, 2012 | 1 | 2012 |
In-Silico and Experimental Detection of Personalized CRISPR Off-Targets Y Pan, C Lee, H Deshmukh, G Bao MOLECULAR THERAPY 28 (4), 456-457, 2020 | | 2020 |
Self-Deletion of AAV-CRISPR Reduces Off-Target Gene Editing In Vivo A Li, CM Lee, AE Hurley, W Lu, M De Giorgi, KE Jarrett, AM Doerfler, ... MOLECULAR THERAPY 27 (4), 89-89, 2019 | | 2019 |
Cell Models of Hemoglobinopathy for Screening Therapeutic Approaches CM Lee, SH Park, Y Zhang, AK Chang, A Paikari, H Deshmukh, ... MOLECULAR THERAPY 26 (5), 379-379, 2018 | | 2018 |
Genome Editing Based Reactivation of Fetal Hemoglobin Expression in HSPCs for Treating Sickle Cell Disease CM Lee, SH Park, Y Zhang, H Deshmukh, TJ Cradick, V Sheehan, G Bao MOLECULAR THERAPY 25 (5), 305-305, 2017 | | 2017 |