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Alexander Gorka
Alexander Gorka
Postdoctoral Fellow, National Cancer Institute
Verified email at nih.gov - Homepage
Title
Cited by
Cited by
Year
A near-IR uncaging strategy based on cyanine photochemistry
AP Gorka, RR Nani, J Zhu, S Mackem, MJ Schnermann
Journal of the American Chemical Society 136 (40), 14153-14159, 2014
2472014
Quinoline drug–heme interactions and implications for antimalarial cytostatic versus cytocidal activities
AP Gorka, A de Dios, PD Roepe
Journal of medicinal chemistry 56 (13), 5231-5246, 2013
1972013
Near‐IR light‐mediated cleavage of antibody–drug conjugates using cyanine photocages
RR Nani, AP Gorka, T Nagaya, H Kobayashi, MJ Schnermann
Angewandte Chemie International Edition 54 (46), 13635-13638, 2015
1812015
Cyanine polyene reactivity: scope and biomedical applications
AP Gorka, RR Nani, MJ Schnermann
Organic & biomolecular chemistry 13 (28), 7584-7598, 2015
1642015
In Vivo Activation of Duocarmycin–Antibody Conjugates by Near-Infrared Light
RR Nani, AP Gorka, T Nagaya, T Yamamoto, J Ivanic, H Kobayashi, ...
ACS central science 3 (4), 329-337, 2017
1372017
Harnessing cyanine reactivity for optical imaging and drug delivery
AP Gorka, RR Nani, MJ Schnermann
Accounts of chemical research 51 (12), 3226-3235, 2018
1192018
Anti-plasmodial polyvalent interactions in Artemisia annua L. aqueous extract–possible synergistic and resistance mechanisms
JO Suberu, AP Gorka, L Jacobs, PD Roepe, N Sullivan, GC Barker, ...
PloS one 8 (11), e80790, 2013
992013
Harnessing cyanine photooxidation: from slowing photobleaching to near-IR uncaging
AP Gorka, MJ Schnermann
Current Opinion in Chemical Biology 33, 117-125, 2016
832016
Glypican‐3‐specific antibody drug conjugates targeting hepatocellular carcinoma
Y Fu, DJ Urban, RR Nani, YF Zhang, N Li, H Fu, H Shah, AP Gorka, ...
Hepatology 70 (2), 563-576, 2019
732019
An intrinsically disordered peptide facilitates non‐endosomal cell entry
SH Medina, SE Miller, AI Keim, AP Gorka, MJ Schnermann, JP Schneider
Angewandte Chemie 128 (10), 3430-3433, 2016
672016
Near-infrared uncaging or photosensitizing dictated by oxygen tension
ED Anderson, AP Gorka, MJ Schnermann
Nature Communications 7 (1), 13378, 2016
652016
Role of fluorophore charge on the in vivo optical imaging properties of near-infrared cyanine dye/monoclonal antibody conjugates
K Sato, AP Gorka, T Nagaya, MS Michie, RR Nani, Y Nakamura, VL Coble, ...
Bioconjugate chemistry 27 (2), 404-413, 2016
642016
The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex
JN Alumasa, AP Gorka, LB Casabianca, E Comstock, AC De Dios, ...
Journal of inorganic biochemistry 105 (3), 467-475, 2011
622011
Antiproliferative and Antiplasmodial Dimeric Phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest
L Harinantenaina, JD Bowman, PJ Brodie, C Slebodnick, MW Callmander, ...
Journal of natural products 76 (3), 388-393, 2013
552013
Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth
AP Gorka, JN Alumasa, KS Sherlach, LM Jacobs, KB Nickley, JP Brower, ...
Antimicrobial agents and chemotherapy 57 (1), 356-364, 2013
542013
Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum
T Dinio, AP Gorka, A McGinniss, PD Roepe, JB Morgan
Bioorganic & medicinal chemistry 20 (10), 3292-3297, 2012
542012
Electrophile-Integrating Smiles Rearrangement Provides Previously Inaccessible C4′-O-Alkyl Heptamethine Cyanine Fluorophores
RR Nani, JB Shaum, AP Gorka, MJ Schnermann
Organic letters 17 (2), 302-305, 2015
522015
Impact of C4′-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates
K Sato, T Nagaya, Y Nakamura, T Harada, RR Nani, JB Shaum, AP Gorka, ...
Molecular pharmaceutics 12 (9), 3303-3311, 2015
412015
Effect of charge localization on the in vivo optical imaging properties of near-infrared cyanine dye/monoclonal antibody conjugates
K Sato, AP Gorka, T Nagaya, MS Michie, Y Nakamura, RR Nani, VL Coble, ...
Molecular BioSystems 12 (10), 3046-3056, 2016
372016
Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis
AP Gorka, LM Jacobs, PD Roepe
Malaria journal 12, 1-9, 2013
372013
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