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Daniel Lai
Daniel Lai
University of British Columbia
Verified email at bccrc.ca - Homepage
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Cited by
Year
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
SP Shah, A Roth, R Goya, A Oloumi, G Ha, Y Zhao, G Turashvili, J Ding, ...
Nature 486 (7403), 395-399, 2012
22972012
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O’Neil, ND Santos, ...
Nature communications 8 (1), 14432, 2017
5082017
Interfaces of malignant and immunologic clonal dynamics in ovarian cancer
AW Zhang, A McPherson, K Milne, DR Kroeger, PT Hamilton, A Miranda, ...
Cell 173 (7), 1755-1769. e22, 2018
3142018
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer
G Ha, A Roth, D Lai, A Bashashati, J Ding, R Goya, R Giuliany, J Rosner, ...
Genome research 22 (10), 1995-2007, 2012
3112012
Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling
AW Zhang, C O’Flanagan, EA Chavez, JLP Lim, N Ceglia, A McPherson, ...
Nature methods 16 (10), 1007-1015, 2019
2902019
Molecular and genetic characterization of MHC deficiency identifies EZH2 as therapeutic target for enhancing immune recognition
D Ennishi, K Takata, W Béguelin, G Duns, A Mottok, P Farinha, ...
Cancer discovery 9 (4), 546-563, 2019
2612019
Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes
YK Wang, A Bashashati, MS Anglesio, DR Cochrane, DS Grewal, G Ha, ...
Nature genetics 49 (6), 856-865, 2017
2592017
Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses
CH O’Flanagan, KR Campbell, AW Zhang, F Kabeer, JLP Lim, J Biele, ...
Genome biology 20, 1-13, 2019
2192019
Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing
E Laks, A McPherson, H Zahn, D Lai, A Steif, J Brimhall, J Biele, B Wang, ...
Cell 179 (5), 1207-1221. e22, 2019
219*2019
On the importance of cotranscriptional RNA structure formation
D Lai, JR Proctor, IM Meyer
Rna 19 (11), 1461-1473, 2013
1812013
Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
SE Arthur, A Jiang, BM Grande, M Alcaide, R Cojocaru, CK Rushton, ...
Nature communications 9 (1), 1-14, 2018
1462018
Genetic profiling of MYC and BCL2 in diffuse large B-cell lymphoma determines cell-of-origin–specific clinical impact
D Ennishi, A Mottok, S Ben-Neriah, HP Shulha, P Farinha, FC Chan, ...
Blood, The Journal of the American Society of Hematology 129 (20), 2760-2770, 2017
1362017
R- chie : a web server and R package for visualizing RNA secondary structures
D Lai, JR Proctor, JYA Zhu, IM Meyer
Nucleic acids research 40 (12), e95-e95, 2012
1342012
Clonal fitness inferred from time-series modelling of single-cell cancer genomes
S Salehi, F Kabeer, N Ceglia, M Andronescu, MJ Williams, KR Campbell, ...
Nature 595 (7868), 585-590, 2021
1062021
clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers
KR Campbell, A Steif, E Laks, H Zahn, D Lai, A McPherson, H Farahani, ...
Genome biology 20, 1-12, 2019
1022019
Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours.
DK Snudden, PR Smith, D Lai, MH Ng, BE Griffin
Oncogene 10 (8), 1545-1552, 1995
911995
A comprehensive comparison of general RNA–RNA interaction prediction methods
D Lai, IM Meyer
Nucleic acids research 44 (7), e61-e61, 2016
692016
TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma
D Ennishi, S Healy, A Bashashati, S Saberi, C Hother, A Mottok, FC Chan, ...
Nature medicine 26 (4), 577-588, 2020
652020
Results of the phase I CCTG IND. 231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies
J Hilton, K Gelmon, PL Bedard, D Tu, H Xu, AV Tinker, R Goodwin, ...
Nature communications 13 (1), 3607, 2022
612022
Single-cell genomic variation induced by mutational processes in cancer
T Funnell, CH O’Flanagan, MJ Williams, A McPherson, S McKinney, ...
Nature 612 (7938), 106-115, 2022
572022
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