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Eugene Hickey
Eugene Hickey
Schrödinger, LLC
Verified email at schrodinger.com
Title
Cited by
Cited by
Year
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
C Pargellis, L Tong, L Churchill, PF Cirillo, T Gilmore, AG Graham, ...
Nature structural biology 9 (4), 268-272, 2002
10532002
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
S Kubicek, RJ O'Sullivan, EM August, ER Hickey, Q Zhang, ML Teodoro, ...
Molecular cell 25 (3), 473-481, 2007
9312007
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate
J Regan, S Breitfelder, P Cirillo, T Gilmore, AG Graham, E Hickey, B Klaus, ...
Journal of medicinal chemistry 45 (14), 2994-3008, 2002
4212002
Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase
KC Qian, L Wang, ER Hickey, J Studts, K Barringer, C Peng, A Kronkaitis, ...
Journal of Biological Chemistry 280 (7), 6130-6137, 2005
3202005
Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea …
J Regan, A Capolino, PF Cirillo, T Gilmore, AG Graham, E Hickey, ...
Journal of medicinal chemistry 46 (22), 4676-4686, 2003
1662003
Aromatic heterocyclic compound as antiinflammatory agents
PF Cirillo, TA Gilmore, ER Hickey, JR Regan, LH Zhang
US Patent 6,319,921, 2001
1442001
The kinetics of binding to p38 MAP kinase by analogues of BIRB 796
J Regan, CA Pargellis, PF Cirillo, T Gilmore, ER Hickey, GW Peet, A Proto, ...
Bioorganic & medicinal chemistry letters 13 (18), 3101-3104, 2003
1262003
Compounds useful as anti-inflammatory agents
S Breitfelder, PF Cirillo, TA Gilmore, ER Hickey, JR Proudfoot, JR Regan, ...
US Patent 6,358,945, 2002
982002
Aromatic heterocyclic compounds and their use as anti-inflammatory agents
JR Regan, PF Cirillo, ER Hickey, N Moss, CL Cywin, C Pargellis, ...
US Patent 6,080,763, 2000
892000
Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode
K Qian, L Wang, CL Cywin, BT Farmer, E Hickey, C Homon, S Jakes, ...
Journal of medicinal chemistry 52 (7), 1814-1827, 2009
812009
Ligands for the Tyrosine Kinase p56lck SH2 Domain:  Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements
PL Beaulieu, DR Cameron, JM Ferland, J Gauthier, E Ghiro, J Gillard, ...
Journal of medicinal chemistry 42 (10), 1757-1766, 1999
781999
Compounds which modulate the CB2 receptor
R Zindell, D Riether, DS Thomson, ER Hickey, I Mushi, M Ermann
US Patent 7,595,397, 2009
742009
Direct elaboration of complex polyquinanes through twofold addition of vinyl anions to squarate esters
J Negri, T Morwick, J Doyon, PD Wilson, ER Hickey, LA Paquette
Journal of the American Chemical Society 115 (25), 12189-12190, 1993
721993
An in silico method for predicting Ames activities of primary aromatic amines by calculating the stabilities of nitrenium ions
J Bentzien, ER Hickey, RA Kemper, ML Brewer, JD Dyekjær, SP East, ...
Journal of chemical information and modeling 50 (2), 274-297, 2010
702010
Isoquinolinone Rho kinase inhibitors
T Bosanac, JD Ginn, ER Hickey, TM Kirrane Jr, W Liu, AS Prokopowicz, ...
US Patent 8,809,326, 2014
692014
A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo
ND Lewis, LA Patnaude, J Pelletier, DJ Souza, SM Lukas, FJ King, JD Hill, ...
PLoS One 9 (6), e100883, 2014
662014
Compounds useful as anti-inflammatory agents
S Breitfelder, PF Cirillo, MH Hao, ER Hickey, R Sharma, S Sun, ...
US Patent 6,492,393, 2002
632002
G Protein–Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a KCa1. 1 (BKCa)–Dependent Mechanism
RM Fryer, KJ Ng, SGN Mazurek, L Patnaude, DJ Skow, A Muthukumarana, ...
Journal of Pharmacology and Experimental Therapeutics 348 (3), 421-431, 2014
532014
Compounds which modulate the CB2 receptor
A Berry, PF Cirillo, D Riether, D Thomson, RM Zindell, N Blumire, ...
US Patent 7,928,123, 2011
492011
Pyrimidine derivatives useful as inhibitors of PKC-theta
AJM Barbosa Jr, SR Brunette, ER Hickey, JM Kim, MD Lawlor, ...
US Patent 7,601,714, 2009
442009
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