| Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired M Ahmadzadeh, LA Johnson, B Heemskerk, JR Wunderlich, ME Dudley, ... Blood 114 (8), 1537-1544, 2009 | 2047 | 2009 |
| Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen LA Johnson, RA Morgan, ME Dudley, L Cassard, JC Yang, MS Hughes, ... Blood 114 (3), 535-546, 2009 | 1717 | 2009 |
| Engineered CAR T cells targeting the cancer-associated Tn-glycoform of the membrane mucin MUC1 control adenocarcinoma AD Posey Jr, RD Schwab, AC Boesteanu, C Steentoft, U Mandel, ... Immunity 44 (6), 1444-1454, 2016 | 583 | 2016 |
| Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity LCS Wang, A Lo, J Scholler, J Sun, RS Majumdar, V Kapoor, M Antzis, ... Cancer immunology research 2 (2), 154-166, 2014 | 533 | 2014 |
| Rational development and characterization of humanized anti–EGFR variant III chimeric antigen receptor T cells for glioblastoma LA Johnson, J Scholler, T Ohkuri, A Kosaka, PR Patel, SE McGettigan, ... Science translational medicine 7 (275), 275ra22-275ra22, 2015 | 491 | 2015 |
| Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions PF Robbins, YF Li, M El-Gamil, Y Zhao, JA Wargo, Z Zheng, H Xu, ... The Journal of Immunology 180 (9), 6116-6131, 2008 | 413 | 2008 |
| Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes LA Johnson, B Heemskerk, DJ Powell, CJ Cohen, RA Morgan, ME Dudley, ... The Journal of Immunology 177 (9), 6548-6559, 2006 | 390 | 2006 |
| Human effector CD8+ T cells derived from naive rather than memory subsets possess superior traits for adoptive immunotherapy CS Hinrichs, ZA Borman, L Gattinoni, Z Yu, WR Burns, J Huang, ... Blood, The Journal of the American Society of Hematology 117 (3), 808-814, 2011 | 364 | 2011 |
| Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma RA Morgan, LA Johnson, JL Davis, Z Zheng, KD Woolard, EA Reap, ... Human gene therapy 23 (10), 1043-1053, 2012 | 343 | 2012 |
| EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss JH Sampson, BD Choi, L Sanchez-Perez, CM Suryadevara, DJ Snyder, ... Clinical Cancer Research 20 (4), 972-984, 2014 | 330 | 2014 |
| Driving gene-engineered T cell immunotherapy of cancer LA Johnson, CH June Cell research 27 (1), 38-58, 2017 | 289 | 2017 |
| T-cell receptor affinity and avidity defines antitumor response and autoimmunity in T-cell immunotherapy S Zhong, K Malecek, LA Johnson, Z Yu, EVS de Miera, F Darvishian, ... Proceedings of the National Academy of Sciences 110 (17), 6973-6978, 2013 | 277 | 2013 |
| Adoptive cell therapy for patients with melanoma, using tumor-infiltrating lymphocytes genetically engineered to secrete interleukin-2 B Heemskerk, K Liu, ME Dudley, LA Johnson, A Kaiser, S Downey, ... Human gene therapy 19 (5), 496-510, 2008 | 178 | 2008 |
| Engineered T cells for cancer therapy CH June, MV Maus, G Plesa, LA Johnson, Y Zhao, BL Levine, SA Grupp, ... Cancer Immunology, Immunotherapy 63 (9), 969-975, 2014 | 150 | 2014 |
| Checkpoint blockade reverses anergy in IL-13Rα2 humanized scFv-based CAR T cells to treat murine and canine gliomas Y Yin, AC Boesteanu, ZA Binder, C Xu, RA Reid, JL Rodriguez, DR Cook, ... Molecular Therapy-Oncolytics 11, 20-38, 2018 | 148 | 2018 |
| EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma H Miao, BD Choi, CM Suryadevara, L Sanchez-Perez, S Yang, G De Leon, ... PloS one 9 (4), e94281, 2014 | 148 | 2014 |
| Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor J Brogdon, LA Johnson, CH June, A Loew, M Maus, J Scholler, H Okada US Patent 9,394,368, 2016 | 123 | 2016 |
| Ocular and systemic autoimmunity after successful tumor-infiltrating lymphocyte immunotherapy for recurrent, metastatic melanoma S Yeh, NK Karne, SP Kerkar, CK Heller, DC Palmer, LA Johnson, Z Li, ... Ophthalmology 116 (5), 981-989. e1, 2009 | 114 | 2009 |
| Structures of MART-126/27–35 peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition OY Borbulevych, FK Insaidoo, TK Baxter, DJ Powell Jr, LA Johnson, ... Journal of molecular biology 372 (5), 1123-1136, 2007 | 112 | 2007 |
| Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells SK Nair, G De Leon, D Boczkowski, R Schmittling, W Xie, J Staats, R Liu, ... Clinical Cancer Research 20 (10), 2684-2694, 2014 | 103 | 2014 |
Steven A RosenbergNCIVerified email at nih.gov
