| Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases YNP Chen, MJ LaMarche, HM Chan, P Fekkes, J Garcia-Fortanet, ... Nature 535 (7610), 148-152, 2016 | 776 | 2016 |
| Evolution of a gram-scale synthesis of (+)-discodermolide AB Smith, TJ Beauchamp, MJ LaMarche, MD Kaufman, Y Qiu, H Arimoto, ... Journal of the American Chemical Society 122 (36), 8654-8664, 2000 | 361 | 2000 |
| Allosteric inhibition of SHP2: identification of a potent, selective, and orally efficacious phosphatase inhibitor J Garcia Fortanet, CHT Chen, YNP Chen, Z Chen, Z Deng, B Firestone, ... Journal of medicinal chemistry 59 (17), 7773-7782, 2016 | 259 | 2016 |
| Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu RP Morris, JA Leeds, HU Naegeli, L Oberer, K Memmert, E Weber, ... Journal of the American Chemical Society 131 (16), 5946-5955, 2009 | 208 | 2009 |
| Gram-scale synthesis of (+)-discodermolide AB Smith, MD Kaufman, TJ Beauchamp, MJ LaMarche, H Arimoto Organic letters 1 (11), 1823-1826, 1999 | 188 | 1999 |
| SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors L Dardaei, HQ Wang, M Singh, P Fordjour, KX Shaw, S Yoda, G Kerr, ... Nature medicine 24 (4), 512-517, 2018 | 185 | 2018 |
| Discovery of LFF571: An Investigational Agent for Clostridium difficile Infection MJ LaMarche, JA Leeds, A Amaral, JT Brewer, SM Bushell, G Deng, ... Journal of medicinal chemistry 55 (5), 2376-2387, 2012 | 141 | 2012 |
| Identification of TNO155, an allosteric SHP2 inhibitor for the treatment of cancer MJ LaMarche, M Acker, A Argintaru, D Bauer, J Boisclair, H Chan, ... Journal of medicinal chemistry 63 (22), 13578-13594, 2020 | 130 | 2020 |
| The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies LA Martello, MJ LaMarche, L He, TJ Beauchamp, AB Smith, SB Horwitz Chemistry & Biology 8 (9), 843-855, 2001 | 125 | 2001 |
| Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition JR LaRochelle, M Fodor, V Vemulapalli, M Mohseni, P Wang, T Stams, ... Nature communications 9 (1), 4508, 2018 | 124 | 2018 |
| Dual allosteric inhibition of SHP2 phosphatase M Fodor, E Price, P Wang, H Lu, A Argintaru, Z Chen, M Glick, HX Hao, ... ACS chemical biology 13 (3), 647-656, 2018 | 112 | 2018 |
| Combinations with allosteric SHP2 inhibitor TNO155 to block receptor tyrosine kinase signaling C Liu, H Lu, H Wang, A Loo, X Zhang, G Yang, C Kowal, S Delach, ... Clinical Cancer Research 27 (1), 342-354, 2021 | 108 | 2021 |
| 6-Amino-3-methylpyrimidinones as potent, selective, and orally efficacious SHP2 inhibitors P Sarver, M Acker, JT Bagdanoff, Z Chen, YN Chen, H Chan, B Firestone, ... Journal of medicinal chemistry 62 (4), 1793-1802, 2019 | 83 | 2019 |
| Efficacy of LFF571 in a hamster model of Clostridium difficile infection A Trzasko, JA Leeds, J Praestgaard, MJ LaMarche, D McKenney Antimicrobial agents and chemotherapy 56 (8), 4459-4462, 2012 | 80 | 2012 |
| Solution structure of (+)-discodermolide AB Smith, MJ LaMarche, M Falcone-Hindley Organic Letters 3 (5), 695-698, 2001 | 80 | 2001 |
| Optimization of fused bicyclic allosteric SHP2 inhibitors JT Bagdanoff, Z Chen, M Acker, YN Chen, H Chan, M Dore, B Firestone, ... Journal of medicinal chemistry 62 (4), 1781-1792, 2019 | 66 | 2019 |
| Structural and functional consequences of three cancer-associated mutations of the oncogenic phosphatase SHP2 JR LaRochelle, M Fodor, X Xu, I Durzynska, L Fan, T Stams, HM Chan, ... Biochemistry 55 (15), 2269-2277, 2016 | 65 | 2016 |
| Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists PR Kym, R Iyengar, AJ Souers, JK Lynch, AS Judd, J Gao, J Freeman, ... Journal of medicinal chemistry 48 (19), 5888-5891, 2005 | 60 | 2005 |
| Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity RS Adams, EF Calderwood, AE Gould, PD Greenspan, MJ LaMarche, ... US Patent 7,652,041, 2010 | 57 | 2010 |
| Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide AB Smith, BS Freeze, MJ LaMarche, T Hirose, I Brouard, PV Rucker, ... Organic Letters 7 (2), 311-314, 2005 | 56 | 2005 |
