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Nicolas Villa-Roel
Nicolas Villa-Roel
Verified email at gatech.edu
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Endothelial reprogramming by disturbed flow revealed by single-cell RNA and chromatin accessibility study
A Andueza, S Kumar, J Kim, DW Kang, HL Mumme, JI Perez, N Villa-Roel, ...
Cell Reports 33 (11), 108491, 2020
1232020
Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia …
J Fernandez Esmerats, N Villa-Roel, S Kumar, L Gu, MT Salim, M Ohh, ...
Arteriosclerosis, Thrombosis, and Vascular Biology 39 (3), 467-481, 2019
642019
Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis
D Williams, M Mahmoud, R Liu, A Andueza, S Kumar, DW Kang, J Zhang, ...
eLife 11, e72579, 2022
272022
Hypoxia inducible factor 1α inhibitor PX-478 reduces atherosclerosis in mice
N Villa-Roel, K Ryu, L Gu, JF Esmerats, DW Kang, S Kumar, H Jo
Atherosclerosis, 2022
172022
miR-214 is stretch-sensitive in aortic valve and inhibits aortic valve calcification
MT Salim, JF Esmerats, S Arjunon, N Villa-Roel, RM Nerem, H Jo, ...
Annals of biomedical engineering 47, 1106-1115, 2019
152019
Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells
C Demos, J Johnson, A Andueza, C Park, Y Kim, N Villa-Roel, DW Kang, ...
Frontiers in Cardiovascular Medicine 9, 979745, 2022
52022
HIF1A inhibitor PX-478 reduces pathological stretch-induced calcification and collagen turnover in aortic valve
MT Salim, N Villa-Roel, B Vogel, H Jo, AP Yoganathan
Frontiers in Cardiovascular Medicine 9, 1002067, 2022
42022
Isolation of Endothelial Cells from the Lumen of Mouse Carotid Arteries for Single-cell Multi-omics Experiments
S Kumar, A Andueza, N Villa-Roel, J Kim, DW Kang, H Jo
JoVE (Journal of Visualized Experiments), e63128, 2021
42021
Role of Biomechanical Stress and Mechanosensitive miRNAs in Calcific Aortic Valve Disease
N Villa-Roel, K Ryu, H Jo
Cardiovascular Calcification and Bone Mineralization, 117-135, 2020
22020
HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells
IA Tamargo, K In Baek, C Xu, D Won Kang, Y Kim, A Andueza, D Williams, ...
Circulation, 2023
12023
Single-Cell RNA sequencing investigation of female-male differences under PAD conditions
GS Marrero, N Villa-Roel, F Li, C Park, DW Kang, KE Hekman, H Jo, ...
Frontiers in Cardiovascular Medicine 10, 2023
12023
Hypoxia Inducible Factor-1α Inhibitor, PX-478, Reduces Atherosclerosis in vivo
N Villa-Roel, L Gu, J Fernandez Esmerats, DW Kang, S Kumar, H Jo
Arteriosclerosis, Thrombosis, and Vascular Biology 40 (Suppl_1), A366-A366, 2020
12020
Myeloid CCN3 protects against aortic valve calcification
P Tu, Q Xu, X Zhou, N Villa-Roel, S Kumar, N Dong, H Jo, C Ou, Z Lin
Cell Communication and Signaling 21 (1), 1-15, 2023
2023
Flow-Induced Cellular Reprogramming in Mouse Atherosclerosis Model
C Park, N Villa-Roel, K JEONG, KI Baek, Y Kim, A Andueza, H Zepeda, ...
Circulation 148 (Suppl_1), A12147-A12147, 2023
2023
Methods and compositions for managing vascular conditions using miR-483 mimics and HIF1alpha pathway inhibitors
H Jo, JF ESMERATS, N Villa-Roel
US Patent 11,225,660, 2022
2022
Abstract MP41: Myeloid Ccn3 Protects Against Aortic Valve Calcification
P Tu, Z Lin, xianming zhou, H Jo, N Villa-roel, S Kumar, C Ou, N Dong
Arteriosclerosis, Thrombosis, and Vascular Biology 41 (Suppl_1), AMP41-AMP41, 2021
2021
Stable Flow-Induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis
D Williams, M Mahmoud, R Liu, A Andueza, S Kumar, DW Kang, J Zhang, ...
bioRxiv, 2021
2021
Endothelial reprogramming by disturbed flow revealed by single-cell RNA and chromatin accessibility study. Cell Rep 33: 108491
A Andueza, S Kumar, J Kim, DW Kang, HL Mumme, JI Perez, N Villa-Roel, ...
2020
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