| MLi-2, a potent, selective, and centrally active compound for exploring the therapeutic potential and safety of LRRK2 kinase inhibition MJ Fell, C Mirescu, K Basu, B Cheewatrakoolpong, DE DeMong, JM Ellis, ... Journal of Pharmacology and Experimental Therapeutics 355 (3), 397-409, 2015 | 257 | 2015 |
| Sonogashira Coupling of 2-iodo-2-cycloalkenones: synthesis of (+)-and (−)-harveynone and (−)-tricholomenyn A MW Miller, CR Johnson The Journal Of Organic Chemistry 62 (6), 1582-1583, 1997 | 201 | 1997 |
| Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 J Lu, N Byrne, J Wang, G Bricogne, FK Brown, HR Chobanian, SL Colletti, ... Nature structural & molecular biology 24 (7), 570-577, 2017 | 165 | 2017 |
| Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression L Lama, C Adura, W Xie, D Tomita, T Kamei, V Kuryavyi, T Gogakos, ... Nature Communications 10 (1), 2261, 2019 | 157 | 2019 |
| Discovery of a 3-(4-pyrimidinyl) indazole (MLi-2), an orally available and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor that reduces brain kinase activity JD Scott, DE DeMong, TJ Greshock, K Basu, X Dai, J Harris, A Hruza, ... Journal of medicinal chemistry 60 (7), 2983-2992, 2017 | 123 | 2017 |
| Synthesis of (+)-1-deoxygalactonojirimycin and a related indolizidine CR Johnson, A Golebiowski, H Sundram, MW Miller, RL Dwaihy Tetrahedron letters 36 (5), 653-654, 1995 | 89 | 1995 |
| Synthesis of aza-C-disaccharides-a new class of sugar mimics CR Johnson, MW Miller, A Golebiowski, H Sundram, MB Ksebati Tetrahedron letters 35 (48), 8991-8994, 1994 | 77 | 1994 |
| Photochemical reaction between tertiary allylic amines and chromium carbene complexes: Synthesis of lactams via a zwitterion aza cope rearrangement CJ Deur, MW Miller, LS Hegedus The Journal of Organic Chemistry 61 (8), 2871-2876, 1996 | 59 | 1996 |
| Enzymic Resolution of a C2 Symmetric Diol Derived from p-Benzoquinone: Synthesis of (+)-and (-)-Bromoxone CR Johnson, MW Miller The Journal of Organic Chemistry 60 (21), 6674-6675, 1995 | 57 | 1995 |
| Mild N-dealkylation of tertiary, benzylic amines with acid chlorides: Application to solid-phase chemistry MW Miller, SF Vice, SW McCombie Tetrahedron letters 39 (21), 3429-3432, 1998 | 55 | 1998 |
| Concise formation of 4-benzyl piperidines and related derivatives using a Suzuki protocol S Vice, T Bara, A Bauer, CA Evans, J Ford, H Josien, S McCombie, ... Journal of Organic Chemistry 66 (7), 2487-2492, 2001 | 53 | 2001 |
| Glucagon receptor antagonists for type II diabetes DE DeMong, MW Miller, JE Lachowicz Annual Reports in Medicinal Chemistry 43, 119-137, 2008 | 49 | 2008 |
| Synthesis of 4-alkyl-4-alkoxybutenolides having unsaturated side chains via chromium carbene complex photochemistry:(+)-cerulenin TE Kedar, MW Miller, LS Hegedus The Journal of Organic Chemistry 61 (18), 6121-6126, 1996 | 45 | 1996 |
| Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells E Mullarky, J Xu, AD Robin, DJ Huggins, A Jennings, N Noguchi, A Olland, ... Bioorganic & medicinal chemistry letters 29 (17), 2503-2510, 2019 | 44 | 2019 |
| Design and synthesis of novel, selective GPR40 AgoPAMs CW Plummer, MJ Clements, H Chen, M Rajagopalan, H Josien, ... ACS medicinal chemistry letters 8 (2), 221-226, 2017 | 30 | 2017 |
| Suzuki arylation of 1, 1-dibromo-1-alkenes: synthesis of tetra-substituted alkenes A Bauer, MW Miller, SF Vice, SW McCombie Synlett 2001 (02), 0254-0256, 2001 | 30 | 2001 |
| Formal olefination and acylaziridination of imidazolones X Dai, MW Miller, AW Stamford Organic Letters 12 (12), 2718-2721, 2010 | 24 | 2010 |
| Tetrahydroquinoline sulfonamides as vasopressin 1b receptor anatgonists JD Scott, MW Miller, SW Li, SI Lin, HA Vaccaro, L Hong, DE Mullins, ... Bioorganic & medicinal chemistry letters 19 (21), 6018-6022, 2009 | 23 | 2009 |
| The Discovery of N-((2H-Tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl … D DeMong, X Dai, J Hwa, M Miller, SI Lin, L Kang, A Stamford, ... Journal of medicinal chemistry 57 (6), 2601-2610, 2014 | 20 | 2014 |
| Discovery of TDI-10229: a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10) M Fushimi, H Buck, M Balbach, A Gorovyy, J Ferreira, T Rossetti, N Kaur, ... ACS Medicinal Chemistry Letters 12 (8), 1283-1287, 2021 | 16 | 2021 |
