| A combinatorial library of lipid-like materials for delivery of RNAi therapeutics A Akinc, A Zumbuehl, M Goldberg, ES Leshchiner, V Busini, N Hossain, ... Nature biotechnology 26 (5), 561-569, 2008 | 1408 | 2008 |
| A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis Y Zou, MJ Palte, AA Deik, H Li, JK Eaton, W Wang, YY Tseng, R Deasy, ... Nature communications 10 (1), 1617, 2019 | 569 | 2019 |
| Development of lipidoid–siRNA formulations for systemic delivery to the liver A Akinc, M Goldberg, J Qin, JR Dorkin, C Gamba-Vitalo, M Maier, ... Molecular Therapy 17 (5), 872-879, 2009 | 459 | 2009 |
| Direct and selective small-molecule activation of proapoptotic BAX E Gavathiotis, DE Reyna, JA Bellairs, ES Leshchiner, LD Walensky Nature chemical biology 8 (7), 639-645, 2012 | 192 | 2012 |
| Biodegradable polymeric vectors for gene delivery to human endothelial cells JJ Green, J Shi, E Chiu, ES Leshchiner, R Langer, DG Anderson Bioconjugate chemistry 17 (5), 1162-1169, 2006 | 187 | 2006 |
| Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices ES Leshchiner, A Parkhitko, GH Bird, J Luccarelli, JA Bellairs, S Escudero, ... Proceedings of the National Academy of Sciences 112 (6), 1761-1766, 2015 | 177 | 2015 |
| Direct activation of full-length proapoptotic BAK ES Leshchiner, CR Braun, GH Bird, LD Walensky Proceedings of the National Academy of Sciences 110 (11), E986-E995, 2013 | 177 | 2013 |
| Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells JJ Green, E Chiu, ES Leshchiner, J Shi, R Langer, DG Anderson Nano letters 7 (4), 874-879, 2007 | 152 | 2007 |
| The retinoblastoma protein induces apoptosis directly at the mitochondria KI Hilgendorf, ES Leshchiner, S Nedelcu, MA Maynard, E Calo, A Ianari, ... Genes & development 27 (9), 1003-1015, 2013 | 151 | 2013 |
| Amine-containing lipids and uses thereof DG Anderson, A Zumbuehl, ES Leshchiner, RS Langer, M Goldberg US Patent 9,006,487, 2015 | 123 | 2015 |
| Ubiquitin ligase TRIM62 regulates CARD9-mediated anti-fungal immunity and intestinal inflammation Z Cao, KL Conway, RJ Heath, JS Rush, ES Leshchiner, ZG Ramirez-Ortiz, ... Immunity 43 (4), 715-726, 2015 | 119 | 2015 |
| Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery KP Mahon, KT Love, KA Whitehead, J Qin, A Akinc, E Leshchiner, ... Bioconjugate chemistry 21 (8), 1448-1454, 2010 | 92 | 2010 |
| Two shot molding method and fastener clip with seal made thereby MDH Clarke US Patent 6,752,950, 2004 | 57 | 2004 |
| Electrostatic coating of particles for drug delivery JJ Green, DG Anderson, RS Langer, E Chiu, ES Leshchiner US Patent App. 12/530,330, 2010 | 54 | 2010 |
| Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease ES Leshchiner, JS Rush, MA Durney, Z Cao, V Dančík, B Chittick, H Wu, ... Proceedings of the National Academy of Sciences 114 (43), 11392-11397, 2017 | 50 | 2017 |
| Amine-containing lipids and uses thereof DG Anderson, A Zumbuehl, ES Leshchiner, RS Langer, MS Goldberg US Patent App. 14/643,845, 2016 | 47 | 2016 |
| Recognition and selective binding of DNA by ionenes of different charge density. ZAN Trukhanova ES, Izumrudov VA, Litmanovich AA Biomacromolecules 6 (6), 3198-201, 2005 | 38 | 2005 |
| HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinoma Y Zou, MJ Palte, AA Deik, H Li, JK Eaton, W Wang, YY Tseng, R Deasy, ... BioRxiv, 388041, 2018 | 10 | 2018 |
| Convergence of resistance patterns in breast cancer after multiple lines of treatment through analysis of rapid autopsy samples I Leshchiner, EE Martin, CT Chen, E Leshchiner, T Zhang, C Pinto, F Utro, ... Cancer Research 81 (13_Supplement), 37-37, 2021 | 1 | 2021 |
| Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices E Leshchiner, J Bellairs, GH Bird, K Opoku-Nsiah, M Godes, LD Walensky Cancer Research 74 (19_Supplement), 2597-2597, 2014 | 1 | 2014 |
