| Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites BS Hall, C Bot, SR Wilkinson Journal of Biological Chemistry 286 (15), 13088-13095, 2011 | 317 | 2011 |
| Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance D Zatreanu, HMR Robinson, O Alkhatib, M Boursier, H Finch, L Geo, ... Nature Communications 12 (1), 1-15, 2021 | 189 | 2021 |
| Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives S R Wilkinson, C Bot, J M Kelly, B S Hall Current Topics in Medicinal Chemistry 11 (16), 2072-2084, 2011 | 151 | 2011 |
| Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi SO Obado, C Bot, D Nilsson, B Andersson, JM Kelly Genome biology 8 (3), 1-14, 2007 | 76 | 2007 |
| Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage C Bot, A Pfeiffer, F Giordano, DE Manjeera, NP Dantuma, L Ström Journal of Cell Science 130 (6), 1134-1146, 2017 | 61 | 2017 |
| Trypanocidal activity of aziridinyl nitrobenzamide prodrugs C Bot, BS Hall, N Bashir, MC Taylor, NA Helsby, SR Wilkinson Antimicrobial agents and chemotherapy 54 (10), 4246-4252, 2010 | 58 | 2010 |
| Evaluating 5-nitrofurans as trypanocidal agents C Bot, BS Hall, G Álvarez, R Di Maio, M González, H Cerecetto, ... Antimicrobial agents and chemotherapy 57 (4), 1638-1647, 2013 | 49 | 2013 |
| Synthesis and structure–activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs L Hu, X Wu, J Han, L Chen, SO Vass, P Browne, BS Hall, C Bot, ... Bioorganic & medicinal chemistry letters 21 (13), 3986-3991, 2011 | 47 | 2011 |
| Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei SO Obado, C Bot, MC Echeverry, JC Bayona, VE Alvarez, MC Taylor, ... Nucleic acids research 39 (3), 1023-1033, 2011 | 31 | 2011 |
| Centromere-associated repeat arrays on Trypanosoma brucei chromosomes are much more extensive than predicted MC Echeverry, C Bot, SO Obado, MC Taylor, JM Kelly BMC genomics 13 (1), 1-8, 2012 | 25 | 2012 |
| A cell-based bioluminescence assay reveals dose-dependent and contextual repression of AP-1-driven gene expression by BACH2 P Vardaka, T Lozano, C Bot, J Ellery, SK Whiteside, CJ Imianowski, ... Scientific reports 10 (1), 1-10, 2020 | 2 | 2020 |
| mRNA Quantification of NIPBL Isoforms A and B in Adult and Fetal Human Tissues, and a Potentially Pathological Variant Affecting Only Isoform A in Two Patients with Cornelia de … B Puisac, ME Teresa-Rodrigo, M Hernández-Marcos, ... International Journal of Molecular Sciences 18 (3), 481, 2017 | 1 | 2017 |
| Trypanosoma cruzi tryparedoxin II in the nucleus: A new perspective on the parasite's antioxidant defenses FR Gadelha, C Bot, MC Taylor, SR Wilkinson Free Radical Biology and Medicine, S90, 2012 | | 2012 |
| Topoisomerase-II mediated biochemical mapping of centromeres and nitroreductase mediated drug metabolism in Trypanosomatids C Bot Queen Mary University of London, 2012 | | 2012 |
Shane Robert WilkinsonHonorary Senior Lecturer, Queen Mary University of LondonVerified email at qmul.ac.uk
