Chimeric antigen receptor–modified T cells for acute lymphoid leukemia SA Grupp, M Kalos, D Barrett, R Aplenc, DL Porter, SR Rheingold, ... New England Journal of Medicine 368 (16), 1509-1518, 2013 | 4050 | 2013 |
CAR T cell immunotherapy for human cancer CH June, RS O’Connor, OU Kawalekar, S Ghassemi, MC Milone Science 359 (6382), 1361-1365, 2018 | 2421 | 2018 |
Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia DL Porter, WT Hwang, NV Frey, SF Lacey, PA Shaw, AW Loren, A Bagg, ... Science translational medicine 7 (303), 303ra139-303ra139, 2015 | 1806 | 2015 |
Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo MC Milone, JD Fish, C Carpenito, RG Carroll, GK Binder, D Teachey, ... Molecular therapy 17 (8), 1453-1464, 2009 | 1383 | 2009 |
Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells OU Kawalekar, RS O’Connor, JA Fraietta, L Guo, SE McGettigan, ... Immunity 44 (2), 380-390, 2016 | 1079 | 2016 |
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains C Carpenito, MC Milone, R Hassan, JC Simonet, M Lakhal, MM Suhoski, ... Proceedings of the National Academy of Sciences 106 (9), 3360-3365, 2009 | 1024 | 2009 |
Clinical use of lentiviral vectors MC Milone, U O’Doherty Leukemia 32 (7), 1529-1541, 2018 | 777 | 2018 |
B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma AD Cohen, AL Garfall, EA Stadtmauer, JJ Melenhorst, SF Lacey, ... The Journal of clinical investigation 129 (6), 2210-2221, 2019 | 637 | 2019 |
Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease CT Ellebrecht, VG Bhoj, A Nace, EJ Choi, X Mao, MJ Cho, G Di Zenzo, ... Science 353 (6295), 179-184, 2016 | 574 | 2016 |
An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer S Feins, W Kong, EF Williams, MC Milone, JA Fraietta American journal of hematology 94 (S1), S3-S9, 2019 | 477 | 2019 |
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis Y Xiang, ZE Stine, J Xia, Y Lu, RS O’Connor, BJ Altman, AL Hsieh, ... The Journal of clinical investigation 125 (6), 2293-2306, 2015 | 447 | 2015 |
Use of chimeric antigen receptor-modified T-cells to treat cancer CH June, BL Levine, DL Porter, MD Kalos, MC Milone US Patent 9,499,629, 2016 | 444 | 2016 |
Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor–transduced human T cells in solid tumors EK Moon, LC Wang, DV Dolfi, CB Wilson, R Ranganathan, J Sun, ... Clinical cancer research 20 (16), 4262-4273, 2014 | 432 | 2014 |
Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules MM Suhoski, TN Golovina, NA Aqui, VC Tai, A Varela-Rohena, ... Molecular Therapy 15 (5), 981-988, 2007 | 318 | 2007 |
Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells MJ Frigault, J Lee, MC Basil, C Carpenito, S Motohashi, J Scholler, ... Cancer immunology research 3 (4), 356-367, 2015 | 311 | 2015 |
Substrate rigidity regulates human T cell activation and proliferation RS O’Connor, X Hao, K Shen, K Bashour, T Akimova, WW Hancock, ... The Journal of Immunology 189 (3), 1330-1339, 2012 | 305 | 2012 |
Compositions for treatment of cancer CH June, BL Levine, DL Porter, MD Kalos, MC Milone US Patent 8,911,993, 2014 | 280 | 2014 |
Methods for treatment of cancer CH June, BL Levine, DL Porter, MD Kalos, MC Milone US Patent 8,906,682, 2014 | 280 | 2014 |
High-affinity GD2-specific CAR T cells induce fatal encephalitis in a preclinical neuroblastoma model SA Richman, S Nunez-Cruz, B Moghimi, LZ Li, ZT Gershenson, ... Cancer immunology research 6 (1), 36-46, 2018 | 255 | 2018 |
F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation A Babich, S Li, RS O'Connor, MC Milone, BD Freedman, JK Burkhardt Journal of Cell Biology 197 (6), 775-787, 2012 | 238 | 2012 |