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Kai Cai, Ph.D.
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Mitochondrial metabolism promotes adaptation to proteotoxic stress
P Tsvetkov, A Detappe, K Cai, HR Keys, Z Brune, W Ying, P Thiru, ...
Nature chemical biology 15 (7), 681-689, 2019
3232019
Human mitochondrial ferredoxin 1 (FDX1) and ferredoxin 2 (FDX2) both bind cysteine desulfurase and donate electrons for iron–sulfur cluster biosynthesis
K Cai, M Tonelli, RO Frederick, JL Markley
Biochemistry 56 (3), 487-499, 2017
1092017
Synthesis, structures, and properties of zinc (II) and cadmium (II) complexes with 1, 2, 4, 5-tetrakis (imidazol-1-ylmethyl) benzene and multicarboxylate ligands
Q Hua, Y Zhao, GC Xu, MS Chen, Z Su, K Cai, WY Sun
Crystal growth & design 10 (6), 2553-2562, 2010
952010
Metamorphic protein IscU alternates conformations in the course of its role as the scaffold protein for iron–sulfur cluster biosynthesis and delivery
JL Markley, JH Kim, Z Dai, JR Bothe, K Cai, RO Frederick, M Tonelli
FEBS letters 587 (8), 1172-1179, 2013
932013
Cadmium (II) complexes with 3, 5-di (1H-imidazol-1-yl) benzoate: topological and structural diversity tuned by counteranions
Z Su, K Cai, J Fan, SS Chen, MS Chen, WY Sun
CrystEngComm 12 (1), 100-108, 2010
792010
Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured …
K Cai, RO Frederick, JH Kim, NM Reinen, M Tonelli, JL Markley
Journal of Biological Chemistry 288 (40), 28755-28770, 2013
642013
Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly
K Cai, RO Frederick, M Tonelli, JL Markley
Journal of inorganic biochemistry 183, 107-116, 2018
582018
Structural/functional properties of human NFU1, an intermediate [4Fe-4S] carrier in human mitochondrial iron-sulfur cluster biogenesis
K Cai, G Liu, RO Frederick, R Xiao, GT Montelione, JL Markley
Structure 24 (12), 2080-2091, 2016
542016
Mitochondrial Cysteine Desulfurase and ISD11 Coexpressed in Escherichia coli Yield Complex Containing Acyl Carrier Protein
K Cai, RO Frederick, M Tonelli, JL Markley
ACS chemical biology 12 (4), 918-921, 2017
402017
The Specialized Hsp70 (HscA) Interdomain Linker Binds to Its Nucleotide-Binding Domain and Stimulates ATP Hydrolysis in Both cis and trans Configurations
TR Alderson, JH Kim, K Cai, RO Frederick, M Tonelli, JL Markley
Biochemistry 53 (46), 7148-7159, 2014
322014
Architectural features of human mitochondrial cysteine desulfurase complexes from crosslinking mass spectrometry and small-angle X-ray scattering
K Cai, RO Frederick, H Dashti, JL Markley
Structure 26 (8), 1127-1136. e4, 2018
292018
pH-dependent self-assembly of copper (II) complexes with a new imidazole-containing polyamine ligand: Synthesis, structure and magnetic property
ZP Qi, ZS Bai, Q Yuan, T Okamura, K Cai, Z Su, WY Sun, N Ueyama
Polyhedron 27 (12), 2672-2680, 2008
272008
Imidazolate-bridged dicopper (II) and copper (II)–zinc (II) complexes of macrocyclic ligand with methylimidazol pendants: Model study of copper (II)–zinc (II) superoxide dismutase
Q Yuan, K Cai, ZP Qi, ZS Bai, Z Su, WY Sun
Journal of inorganic biochemistry 103 (8), 1156-1161, 2009
262009
ISCU (M108I) and ISCU (D39V) differ from wild-type ISCU in their failure to form cysteine desulfurase complexes containing both frataxin and ferredoxin
K Cai, RO Frederick, M Tonelli, JL Markley
Biochemistry 57 (9), 1491-1500, 2018
192018
Imidazolate-bridged dinuclear copper (II) complex with new macrocyclic ligand bearing two 1H-imidazol-4-yl-pendants
ZP Qi, K Cai, Q Yuan, T Okamura, ZS Bai, WY Sun, N Ueyama
Inorganic Chemistry Communications 13 (7), 847-851, 2010
182010
ISCU interacts with NFU1, and ISCU [4Fe-4S] transfers its Fe-S cluster to NFU1 leading to the production of holo-NFU1
K Cai, RO Frederick, JL Markley
Journal of structural biology 210 (2), 107491, 2020
172020
NMR as a tool to investigate the processes of mitochondrial and cytosolic iron-sulfur cluster biosynthesis
K Cai, JL Markley
Molecules 23 (9), 2213, 2018
122018
Cryo-electron microscopic analysis of single-pass transmembrane receptors
K Cai, X Zhang, X Bai
Chemical reviews 122 (17), 13952-13988, 2022
112022
Conformational flexibility in the enterovirus RNA replication platform
MS Warden, K Cai, G Cornilescu, JE Burke, K Ponniah, SE Butcher, ...
RNA 25 (3), 376-387, 2019
112019
Cryo-tomography reveals rigid-body motion and organization of apicomplexan invasion machinery
L Gui, WJ O’Shaughnessy, K Cai, E Reetz, ML Reese, D Nicastro
Nature communications 14 (1), 1775, 2023
82023
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