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Rebecca Fairclough
Rebecca Fairclough
Associate Principal Scientist, Bioscience, AstraZeneca
Verified email at astrazeneca.com - Homepage
Title
Cited by
Cited by
Year
Therapy for Duchenne muscular dystrophy: renewed optimism from genetic approaches
RJ Fairclough, MJ Wood, KE Davies
Nature Reviews Genetics 14 (6), 373-378, 2013
3122013
Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse
JM Tinsley, RJ Fairclough, R Storer, FJ Wilkes, AC Potter, SE Squire, ...
PloS one 6 (5), e19189, 2011
2142011
The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions
J Vanoevelen, L Dode, K Van Baelen, RJ Fairclough, L Missiaen, ...
Journal of biological chemistry 280 (24), 22800-22808, 2005
1582005
Calcium pumps and keratinocytes: lessons from Darier's disease and Hailey–Hailey disease
J Dhitavat, RJ Fairclough, A Hovnanian, SM Burge
British Journal of Dermatology 150 (5), 821-828, 2004
1552004
Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)
RJ Fairclough, L Dode, J Vanoevelen, JP Andersen, L Missiaen, ...
Journal of Biological Chemistry 278 (27), 24721-24730, 2003
1332003
Hailey-Hailey disease: molecular and clinical characterization of novel mutations in the ATP2C1 gene
C Dobson-Stone, R Fairclough, E Dunne, J Brown, AP Monaco, ...
Journal of investigative dermatology 118 (2), 338-343, 2002
1292002
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2
IV Grigorieva, S Mirczuk, KU Gaynor, MA Nesbit, EF Grigorieva, Q Wei, ...
The Journal of clinical investigation 120 (6), 2144-2155, 2010
1212010
Human myometrial genes are differentially expressed in labor: a suppression subtractive hybridization study
EC Chan, S Fraser, S Yin, G Yeo, K Kwek, RJ Fairclough, R Smith
The Journal of Clinical Endocrinology & Metabolism 87 (6), 2435-2441, 2002
1162002
Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin
D Li, A Bareja, L Judge, Y Yue, Y Lai, R Fairclough, KE Davies, ...
Journal of cell science 123 (12), 2008-2013, 2010
1122010
Changes in matrix metalloproteinase (MMP)-2 and MMP-9 in the fetal amnion and chorion during gestation and at term and preterm labor
H Yonemoto, CB Young, JT Ross, LL Guilbert, RJ Fairclough, DM Olson
Placenta 27 (6-7), 669-677, 2006
912006
Progress in therapy for Duchenne muscular dystrophy
RJ Fairclough, A Bareja, KE Davies
Experimental physiology 96 (11), 1101-1113, 2011
842011
11β-Hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial
K Markey, J Mitchell, H Botfield, RS Ottridge, T Matthews, A Krishnan, ...
Brain Communications 2 (1), fcz050, 2020
632020
Hailey–Hailey disease: identification of novel mutations in ATP2C1 and effect of missense mutation A528P on protein expression levels
RJ Fairclough, L Lonie, K Van Baelen, M Haftek, CS Munro, SM Burge, ...
Journal of investigative dermatology 123 (1), 67-71, 2004
532004
11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in idiopathic intracranial hypertension
RS Hardy, H Botfield, K Markey, JL Mitchell, Z Alimajstorovic, ...
The Journal of Clinical Endocrinology & Metabolism 106 (1), 174-187, 2021
492021
Public-private partnerships: compound and data sharing in drug discovery and development
AM Davis, O Engkvist, RJ Fairclough, I Feierberg, A Freeman, P Iyer
SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (5), 604-619, 2021
252021
Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial
RA Ajjan, EMA Hensor, F Del Galdo, K Shams, A Abbas, RJ Fairclough, ...
European journal of endocrinology 186 (4), 441-455, 2022
182022
Discovery and mechanism of action studies of 4, 6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy
A Vuorinen, IVL Wilkinson, M Chatzopoulou, B Edwards, SE Squire, ...
European Journal of Medicinal Chemistry 220, 113431, 2021
122021
Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge
BE Ford, SS Chachra, A Alshawi, A Brennan, S Harnor, C Cano, DJ Baker, ...
Diabetes, Obesity and Metabolism 22 (11), 1985-1994, 2020
122020
Clinic‐ready inhibitor of MMP‐9/‐12 restores sensory and functional decline in rodent models of spinal cord injury
Z Ahmed, S Alhajlah, AM Thompson, RJ Fairclough
Clinical and Translational Medicine 12 (5), 2022
92022
Effect of AZD4017, a selective 11β-HSD1 inhibitor, on bone turnover markers in postmenopausal osteopenia
A Abbas, M Schini, G Ainsworth, SR Brown, J Oughton, RK Crowley, ...
The Journal of Clinical Endocrinology & Metabolism 107 (7), 2026-2035, 2022
62022
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