Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases PJ Weathers, PR Arsenault, PS Covello, A McMickle, KH Teoh, DW Reed Phytochemistry Reviews 10, 173-183, 2011 | 230 | 2011 |
Recent advances in artemisinin production through heterologous expression PR Arsenault, KK Wobbe, PJ Weathers Current medicinal chemistry 15 (27), 2886-2896, 2008 | 104 | 2008 |
Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua PR Arsenault, D Vail, KK Wobbe, K Erickson, PJ Weathers Plant Physiology 154 (2), 958-968, 2010 | 93 | 2010 |
Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing D Song, L Li, PR Arsenault, Q Tan, AW Bigham, KJ Heaton-Johnson, ... Journal of Biological Chemistry 289 (21), 14656-14665, 2014 | 90 | 2014 |
DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures A Mannan, C Liu, PR Arsenault, MJ Towler, DR Vail, A Lorence, ... Plant cell reports 29, 143-152, 2010 | 84 | 2010 |
Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L. KT Nguyen, PR Arsenault, PJ Weathers In Vitro Cellular & Developmental Biology-Plant 47, 329-338, 2011 | 76 | 2011 |
Prolyl hydroxylase domain protein 2 (PHD2) binds a Pro-Xaa-Leu-Glu motif, linking it to the heat shock protein 90 pathway D Song, LS Li, KJ Heaton-Johnson, PR Arsenault, SR Master, FS Lee Journal of Biological Chemistry 288 (14), 9662-9674, 2013 | 64 | 2013 |
Effect of Sugars on Artemisinin Production in Artemisia annua L.: Transcription and Metabolite Measurements PR Arsenault, DR Vail, KK Wobbe, PJ Weathers Molecules 15 (4), 2302-2318, 2010 | 62 | 2010 |
A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism PR Arsenault, F Pei, R Lee, H Kerestes, MJ Percy, B Keith, MC Simon, ... Journal of Biological Chemistry 288 (47), 33571-33584, 2013 | 54 | 2013 |
The role of PHD2 mutations in the pathogenesis of erythrocytosis B Gardie, MJ Percy, D Hoogewijs, R Chowdhury, C Bento, PR Arsenault, ... Hypoxia 2, 71-90, 2014 | 51 | 2014 |
Chemical approaches to intervening in ubiquitin specific protease 7 (USP7) function for oncology and immune oncology therapies J Wu, S Kumar, F Wang, H Wang, L Chen, P Arsenault, M Mattern, ... Journal of medicinal chemistry 61 (2), 422-443, 2018 | 40 | 2018 |
Identification of prolyl hydroxylation modifications in mammalian cell proteins PR Arsenault, KJ Heaton‐Johnson, L Li, D Song, VS Ferreira, N Patel, ... Proteomics 15 (7), 1259-1267, 2015 | 27 | 2015 |
The zinc finger of prolyl hydroxylase domain protein 2 is essential for efficient hydroxylation of hypoxia-inducible factor α PR Arsenault, D Song, YJ Chung, TS Khurana, FS Lee Molecular and Cellular Biology 36 (18), 2328-2343, 2016 | 17 | 2016 |
Identification of Small‐Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor PR Arsenault, D Song, M Bergkamp, AM Ravaschiere, BE Navalsky, ... ChemBioChem 17 (24), 2316-2323, 2016 | 8 | 2016 |
Exogenous sugars affect Artemisinin production in Artemisia annua L transcription and metabolite measurements P Arsenault, D Vail, K Wobbe, P Weathers IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 46, S83-S84, 2010 | 2 | 2010 |
Effects of Developmental Stage, Exogenous Sugar Composition, and Reactive Oxygen Species on Artemisinin and Related Compounds in Artemisia Annua PR Arsenault Worcester Polytechnic Institute, 2010 | | 2010 |
Expression of a pharmacologically important terpenoid metabolic pathway from artemisia annua in Solanum lycopersicon. PR Arsenault, PJ Weathers, KL Wobbe IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL 43, S52-S52, 2007 | | 2007 |