| Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents H Zhao, AC Donnelly, BR Kusuma, GEL Brandt, D Brown, RA Rajewski, ... Journal of medicinal chemistry 54 (11), 3839-3853, 2011 | 185 | 2011 |
| Novobiocin analogues having modified sugar moieties BSJ Blagg, H Zhao, AC Donnelly US Patent 9,120,774, 2015 | 119 | 2015 |
| Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy MJ Urban, P Pan, KL Farmer, H Zhao, BSJ Blagg, RT Dobrowsky Experimental neurology 235 (1), 388-396, 2012 | 91 | 2012 |
| 3-Arylcoumarin derivatives manifest anti-proliferative activity through Hsp90 inhibition H Zhao, B Yan, LB Peterson, BSJ Blagg ACS medicinal chemistry letters 3 (4), 327-331, 2012 | 88 | 2012 |
| Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy J Ma, KL Farmer, P Pan, MJ Urban, H Zhao, BSJ Blagg, RT Dobrowsky Journal of Pharmacology and Experimental Therapeutics 348 (2), 281-292, 2014 | 82 | 2014 |
| Identification and initial SAR of silybin: an Hsp90 inhibitor H Zhao, GE Brandt, L Galam, RL Matts, BSJ Blagg Bioorganic & medicinal chemistry letters 21 (9), 2659-2664, 2011 | 77 | 2011 |
| Targeting the heat shock protein 90 dimer with dimeric inhibitors BR Kusuma, LB Peterson, H Zhao, G Vielhauer, J Holzbeierlein, ... Journal of medicinal chemistry 54 (18), 6234-6253, 2011 | 67 | 2011 |
| C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons L Zhang, H Zhao, BSJ Blagg, RT Dobrowsky Journal of proteome research 11 (4), 2581-2593, 2012 | 63 | 2012 |
| Exploiting conformational dynamics in drug discovery: design of C-terminal inhibitors of Hsp90 with improved activities E Moroni, H Zhao, BSJ Blagg, G Colombo Journal of chemical information and modeling 54 (1), 195-208, 2014 | 62 | 2014 |
| Hsp90 modulation for the treatment of Alzheimer’s disease H Zhao, ML Michaelis, BSJ Blagg Advances in pharmacology 64, 1-25, 2012 | 61 | 2012 |
| Novel HSP90 inhibitors effectively target functions of thyroid cancer stem cell preventing migration and invasion PT White, C Subramanian, Q Zhu, H Zhang, H Zhao, R Gallagher, ... Surgery 159 (1), 142-151, 2016 | 48 | 2016 |
| Synthesis and evaluation of noviose replacements on novobiocin that manifest antiproliferative activity H Zhao, B Reddy Kusuma, BSJ Blagg ACS medicinal chemistry letters 1 (7), 311-315, 2010 | 48 | 2010 |
| Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors H Zhao, G Garg, J Zhao, E Moroni, A Girgis, LS Franco, S Singh, ... European journal of medicinal chemistry 89, 442-466, 2015 | 47 | 2015 |
| KU675, a concomitant heat-shock protein inhibitor of Hsp90 and Hsc70 that manifests isoform selectivity for Hsp90α in prostate cancer cells W Liu, GA Vielhauer, JM Holzbeierlein, H Zhao, S Ghosh, D Brown, E Lee, ... Molecular pharmacology 88 (1), 121-130, 2015 | 45 | 2015 |
| Identification of a new scaffold for Hsp90 C-terminal inhibition H Zhao, E Moroni, G Colombo, BSJ Blagg ACS Medicinal Chemistry Letters 5 (1), 84-88, 2014 | 43 | 2014 |
| Syntheses and properties of cross‐linked polymers from functionalized triglycerides HP Zhao, JF Zhang, X Susan Sun, DH Hua Journal of applied polymer science 110 (2), 647-656, 2008 | 41 | 2008 |
| Triazole containing novobiocin and biphenyl amides as Hsp90 C-terminal inhibitors J Zhao, H Zhao, JA Hall, D Brown, E Brandes, J Bazzill, PT Grogan, ... MedChemComm 5 (9), 1317-1323, 2014 | 40 | 2014 |
| Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun C Li, J Ma, H Zhao, BSJ Blagg, RT Dobrowsky ASN neuro 4 (7), 20120047, 2012 | 39 | 2012 |
| Cytotoxic sugar analogues of an optimized novobiocin scaffold AC Donnelly, H Zhao, BR Kusuma, BSJ Blagg MedChemComm 1 (2), 165-170, 2010 | 38 | 2010 |
| Novobiocin analogues with second-generation noviose surrogates H Zhao, BSJ Blagg Bioorganic & medicinal chemistry letters 23 (2), 552-557, 2013 | 36 | 2013 |
