Yun-Hee Youm, Kim Y Nguyen, Ryan W Grant, Emily L Goldberg, Monica Bodogai, Dongin Kim, Dominic D'agostino, Noah Planavsky, Christopher Lupfer, Thirumala D Kanneganti, Seokwon Kang, Tamas L Horvath, Tarek M Fahmy, Peter A Crawford, Arya Biragyn, Emad Alnemri, Vishwa Deep Dixit

2015/3/1

Nature medicine

21

3

263-269

Nature Research

The ketone bodies β-hydroxybutyrate (BHB) and acetoacetate (AcAc) support mammalian
survival during states of energy deficit by serving as alternative sources of ATP 1. BHB levels
are elevated by starvation, caloric restriction, high-intensity exercise, or the low-
carbohydrate ketogenic diet 2. Prolonged fasting reduces inflammation; however, the impact
that ketones and other alternative metabolic fuels produced during energy deficits have on
the innate immune response is unknown 2, 3, 4, 5, 6. We report that BHB, but neither AcAc ...