Zachary Lewis, James Hanken

2015/4/1

The FASEB Journal

29

1 Supplement

552.2

Federation of American Societies for Experimental Biology

Abstract Congenital atrial septal defects (ASDs) rank among the three most common birth
defects in humans. However, the proportion of ASDs with a known genetic basis is small.
New methods, models and systems for studying ASD are needed to further our
understanding of its etiology and to develop possible treatments. We demonstrate that
salamanders offer an effective model for studying ASD. Surprisingly, most salamander
species have no lungs. By making 3-D reconstructions of a broad sample of salamander ...