Matthew N McCarroll, Zachary R Lewis, Maya Deza Culbertson, Benjamin L Martin, David Kimelman, Alex V Nechiporuk

2012/8/1

Development

139

15

2740-2750

Oxford University Press for The Company of Biologists Limited

Summary Pax gene haploinsufficiency causes a variety of congenital defects. Renal-
coloboma syndrome, resulting from mutations in Pax2, is characterized by kidney
hypoplasia, optic nerve malformation, and hearing loss. Although this underscores the
importance of Pax gene dosage in normal development, how differential levels of these
transcriptional regulators affect cell differentiation and tissue morphogenesis is still poorly
understood. We show that differential levels of zebrafish Pax2a and Pax8 modulate ...