- ►oxfordjournals.org SD Dib-Hajj, AM Rush, TR Cummins, FM … - Brain, 2005 - Oxford Univ Press Erythromelalgia is an autosomal dominant disorder characterized by burning pain
in response to warm stimuli or moderate exercise. We describe a novel mutation
in a family with erythromelalgia in SCN9A, the gene that encodes the Na v ... Cited by 102 - Related articles - BL Direct - All 7 versions
- ►physoc.org PL Sheets, JO Jackson, SG Waxman, SD Dib- … - The Journal of physiology, 2007 - Physiological Soc Mutations in the TTX-sensitive voltage-gated sodium channel subtype Na v 1.7
have been implicated in the painful inherited neuropathy, hereditary erythromelalgia. Hereditary erythromelalgia can be difficult to treat and, ... Cited by 23 - Related articles - BL Direct - All 11 versions
- ►jneurosci.org TP Harty, SD Dib-Hajj, L Tyrrell, R … - Journal of Neuroscience, 2006 - Soc Neuroscience Inherited erythromelalgia/erythermalgia (IEM) is a neuropathy characterized by
pain and redness of the extremities that is triggered by warmth. IEM has been
associated with missense mutations of the voltage-gated sodium channel Na v ... Cited by 33 - Related articles - All 6 versions
SP Novella, FM Hisama, SD Dib-Hajj, SG … - Nat Clin Pract Neurol, 2007 - medscape.com A 15-year-old boy presented to his primary care physician with a lifelong
history of episodic erythema, mild swelling, and painful burning sensations in
the distal extremities that affected his hands, feet (Figure 1), ears, and ... Cited by 7 - Related articles - All 6 versions
- ►jbc.org A Lampert, AO O'Reilly, SD Dib-Hajj, L … - Journal of Biological Chemistry, 2008 - ASBMB Sodium channel Na v 1.7 has recently elicited considerable interest as a key
contributor to human pain. Gain-of-function mutations of Na v 1.7 produce
painful disorders, whereas loss-of-function Na v 1.7 mutations produce ... Related articles - All 4 versions
- ►jneurosci.org M Estacion, SD Dib-Hajj, PJ Benke, RHM te … - Journal of Neuroscience, 2008 - Soc Neuroscience Gain-of-function mutations of Na V 1.7 have been shown to produce two distinct
disorders: Na V 1.7 mutations that enhance activation produce inherited erythromelalgia (IEM), characterized by burning pain in the extremities; Na ... Cited by 5 - Related articles - All 7 versions
TZ Fischer, ES Gilmore, M Estacion, E … - Annals of Neurology, 2009 - interscience.wiley.com Human and animal studies have shown that Na v 1.7 sodium channels, which are
preferentially expressed within nociceptors and sympathetic neurons, play a
major role in inflammatory and neuropathic pain. Inherited erythromelalgia ... Related articles - All 3 versions
- ►jbc.org A Lampert, SD Dib-Hajj, L Tyrrell, SG … - Journal of Biological Chemistry, 2006 - ASBMB The Nav1.7 sodium channel is preferentially expressed in most nociceptive dorsal
root ganglion neurons and in sympathetic neurons. Inherited erythromelalgia
(IEM, also known as erythermalgia), an autosomal dominant neuropathy ... Cited by 22 - Related articles - All 7 versions
X Cheng, SD Dib-Hajj, L Tyrrell, SG Waxman - Molecular pain, 2008 - molecularpain.com Primary erythromelalgia is an autosomal dominant pain disorder characterized by
burning pain and skin redness in the extremities, with onset of symptoms during
the first decade in the families whose mutations have been physiologically ... Cited by 8 - Related articles - Cached - All 12 versions
C Han, SD Dib-Hajj, Z Lin, Y Li, EM Eastman, … - Brain, 2009 - Oxford Univ Press Inherited erythromelalgia (IEM), an autosomal dominant disorder characterized by
severe burning pain in response to mild warmth, has been shown to be caused by
gain-of-function mutations of sodium channel Na v 1.7 which is ... Cited by 3 - Related articles - All 3 versions
JS Choi, L Zhang, SD Dib-Hajj, C Han, L … - Experimental Neurology, 2009 - Elsevier Inherited erythromelalgia (IEM), characterized by episodic burning pain and
erythema of the extremities, is produced by gain-of-function mutations in sodium
channel Na v 1.7, which is preferentially expressed in nociceptive and ... Cited by 4 - Related articles - All 2 versions
[CITATION] Sporadic onset of hereditary erythromelalgia: a gain-of-function mutation in Na v 1.7
MJ Lee, HS Yu, ST Hsieh, DA Stephenson, … - Journal of neurology, 2007 - Springer Familial primary erythromelalgia (OMIM: 133020) is a rare autosomal dominant
disorder mapping to human chromosome 2q24 [5, 12]. It is characterized by
intermittent redness associated with burning pain in the extremities, ... Cited by 15 - Related articles - BL Direct - All 5 versions
MDP Davis, RH Weenig, J Genebriera, G … - Journal of the American Academy of Dermatology, 2006 - Elsevier Erythromelalgia, initially described more than a century ago, 1 and 2 is a rare
clinical syndrome defined by intermittent or continuous flushing of acral areas
such as the feet and hands. The flushing is associated with heat and ... Cited by 8 - Related articles - All 13 versions
[CITATION] A Navl. 7 channel mutation associated with hereditary erythromelalgia contributes to neuronal …
SG Waxman, SD Dib-Hajj - Annals of neurology, 2005 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 14 - Related articles - All 4 versions
A Lampert, SD Dib-Hajj, EM Eastman, L … - Biochemical and Biophysical Research …, 2009 - Elsevier Erythromelalgia (also termed erythermalgia) is a neuropathic pain syndrome,
characterized by severe burning pain combined with redness in the extremities,
triggered by mild warmth. The inherited form of erythromelalgia (IEM) has ...
MDP Davis, J Genebriera, P Sandroni, RD … - Archives of Dermatology, 2006 - Am Med Assoc You are seeing this message because your Web browser does not support basic Web
standards. Find out more about why this message is appearing and what you can do
to make your experience on this site better. ... Objectives To examine the ... Cited by 3 - Related articles - BL Direct - All 4 versions
- ►shouxi.net A Nathan, JB Rose, JW Guite, D Hehir, K … - Pediatrics, 2005 - Am Acad Pediatrics Erythromelalgia is a rare, chronic, debilitating condition characterized by
redness, warmth, and severe burning pain of the distal extremities. The feet are
more commonly affected than the hands. Pain is precipitated by increases in ... Cited by 21 - Related articles - All 9 versions
JS Choi, L Zhang, SD Dib-Hajj, C Han, L … - Biophysical Journal, 2009 - Elsevier Inherited erythromelalgia (IEM), characterized by episodic burning pain and
erythema of the extremities, is produced by gain-of-function mutations in sodium
channel Na v 1.7, which is preferentially expressed in nociceptive and ... All 2 versions
N Kumar, MDP Davis - Mayo Clinic Proceedings, 2006 - mayoclinproc.highwire.org A 43-year-old woman was evaluated because of a 6-month history of intermittent
tingling in her feet accompanied by redness, warmth, and pain. Exposure to heat
and exercise often precipitated her symptoms. Results of neurological ... All 8 versions
C Han, A Lampert, AM Rush, SD Dib-Hajj, X … - Molecular Pain, 2007 - molecularpain.com The disabling chronic pain syndrome erythromelalgia (also termed erythermalgia)
is characterized by attacks of burning pain in the extremities induced by
warmth. Pharmacological treatment is often ineffective, but the pain can be ... Cited by 5 - Related articles - Cached - All 7 versions
SG Waxman - European Journal of Pain, 2007 - Elsevier Studies in vitro and in subhuman models strongly suggest that sodium channels
contribute to pain by producing hyperexcitability of nociceptive DRG neurons.
However, evidence for a role of sodium channels in human pain has been more ...
SD Dib-Hajj, AM Rush, TR Cummins, SG … - Drug Discovery Today: Disease Mechanisms, 2006 - Elsevier SCN9A-related inherited erythromelalgia (also known as erythermalgia; IEM) is a
rare, autosomal dominant disorder that until recently was of enigmatic etiology
[1]. IEM is characterized by recurrent and symmetric attacks of intense ... Cited by 2 - Related articles
MDP Davis, T Rooke - Current treatment options in cardiovascular medicine, 2006 - Springer Introduction Erythromelalgia is a rare and frequently devastating clini- cal
syndrome. The term erythromelalgia describes the clin- ical features: erythros
(redness), melos (extremity), and algia (pain). It has been suggested that ... Cited by 14 - Related articles - BL Direct - All 9 versions
O Uyanik, C Quiles, H Bostock, S Dib-Hajj, T … - European Journal of Pain, 2007 - Elsevier Results. Patients complained of spontaneous burning pain, mechanical and heat
hyperalgesia, and red discoloration of the feet and face. EMG/NCS: normal. LEP:
normal “late” (A-δ fiber) and absent “ultralate” potentials ...
MDP Davis, F Wilkins, TW Rooke - Archives of Dermatology, 2006 - archderm.highwire.org Although the syndrome of erythromelalgia has been well documented in recent
years, the reason that the extremities suddenly turn hot and red remains
elusive. In recent years, some clues have been elucidated, such as ... BL Direct - All 3 versions
JS Cohen - Archives of Dermatology, 2006 - archderm.highwire.org I would like to offer some comments on the excellent article by Sandroni and
Davis 1 on topical transdermal amitriptyline and ketamine for severe erythromelalgia. From my own work with patients with erythromelalgia and as ... BL Direct - All 3 versions
