- ►aspetjournals.org P Pacher, S Batkai, G Kunos - Pharmacological reviews, 2006 - ASPET The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered
an exponential growth of studies exploring the endocannabinoid system and its regulatory functions
in health and disease. Such studies have been greatly facilitated by the introduction of ... Cited by 342 - Related articles - BL Direct - All 14 versions
RG Pertwee - International Journal of Obesity, 2006 - nature.com Mammalian tissues express at least two cannabinoid receptor types, CB 1 and CB 2 , both G
protein coupled. CB 1 receptors are found predominantly at nerve terminals where they mediate
inhibition of transmitter release. CB 2 receptors occur mainly on immune cells, one of their ... Cited by 53 - Related articles - BL Direct - All 5 versions
RG Pertwee - British Journal of Pharmacology, 2008 - pubmedcentral.nih.gov Cannabis sativa is the source of a unique set of compounds known collectively as plant cannabinoids
or phytocannabinoids. This review focuses on the manner with which three of these
compounds, (−)-trans-Δ 9 -tetrahydrocannabinol (Δ 9 -THC), (−)-cannabidiol (CBD) and ... Cited by 49 - Related articles - BL Direct - All 5 versions
M Bifulco, C Laezza, S Pisanti, P … - British journal of …, 2006 - pubmedcentral.nih.gov In the last two decades, research has dramatically increased the knowledge of cannabinoids
biology and pharmacology. In mammals, compounds with properties similar to active components
of Cannabis sativa, the so called 'endocannabinoids', have been shown to modulate key ... Cited by 44 - Related articles - BL Direct - All 7 versions
TW Klein, GA Cabral - Journal of Neuroimmune Pharmacology, 2006 - Springer Abstract The study of marijuana cannabinoid biology has led to many important discoveries in
neuroscience and immunology. These studies have uncovered a new physiological system,
the endocannabinoid system, which operates in the regulation of not only brain function ... Cited by 22 - Related articles - BL Direct - All 2 versions
L Mestre, F Correa, F Docagne, D Clemente, C … - Biochemical …, 2006 - Elsevier Brain endothelial cells infection represents one of the first events in the pathogenesis of
TMEV-induced demyelination disease (TMEV-IDD), a model of multiple sclerosis (MS). The fact
that cyclooxygenase-2 (COX-2) expression in brain endothelium mediates a wide variety ... Cited by 16 - Related articles - All 4 versions
- ►iovs.org C Nucci, V Gasperi, R Tartaglione, A Cerulli, A … - … ophthalmology & visual …, 2007 - ARVO From 1 Physiopathological Optics, Department of Biopathology and Diagnostic Imaging, and
the 5 Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor
Vergata, Rome, Italy; 2 IRCCS (Istituti di Ricovero e Cura a Carattere Scientifico) ... Cited by 15 - Related articles - BL Direct - All 4 versions
RG Pertwee - Addiction Biology, 2008 - interscience.wiley.com A major finding—that (–)-trans-Δ 9 -tetrahydrocannabinol (Δ 9 -THC) is largely responsible for
the psychotropic effects of cannabis—prompted research in the 1970s and 1980s that led to
the discovery that this plant cannabinoid acts through at least two types of cannabinoid ... Cited by 13 - Related articles - BL Direct - All 3 versions
T Georgieva, S Devanathan, D Stropova, CK Park, … - European journal of …, 2008 - Elsevier Cannabinoid drugs differ in their rank order of potency to produce analgesia versus other central
nervous system effects. We propose that these differences are due to unique agonist-bound
cannabinoid CB 1 receptor conformations that exhibit different affinities for individual ... Cited by 11 - Related articles - All 4 versions
I Tomida, A Azuara-Blanco, H House, M Flint, RG … - Journal of …, 2006 - journals.lww.com Ileana Tomida, MD,* Augusto Azuara-Blanco, MD, PhD,* Heather House, BSc,w Maggie
Flint, BSc,z Roger G. Pertwee, DPhil, DSc,y and Philip J. Robson, MDw ... Purpose: The purpose
of this study was to assess the effect on intraocular pressure (IOP) and the safety and ... Cited by 12 - Related articles - BL Direct - All 17 versions
