AW Stitt - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2005 - interscience.wiley.com Abstract: Diabetes and age-related eye disorders remain leading causes of
blindness worldwide. While defined pathogenic mechanisms for many of these
diseases remain elusive, there is increasing evidence that products of the ... Cited by 34 - Related articles - BL Direct - All 6 versions
P Canning, JV Glenn, DK Hsu, FT Liu, TA … - Exp Diabetes Res, 2007 - hindawi.com Breakdown of the inner blood-retinal barrier (iBRB) occurs early in diabetes and
is central to the development of sight-threatening diabetic macular edema (DME)
as retinopathy progresses. In the current study, we examined how advanced ... Cited by 11 - Related articles - View as HTML - All 15 versions
SF Yan, R Ramasamy, AM Schmidt - Journal of Molecular Medicine, 2009 - Springer Abstract The actors in the pathogenesis of diabetes and its complications are
many and multifaceted. The effects of elevated levels of glucose are myriad;
among these is the generation of advanced glycation end products (AGEs), ... Cited by 5 - Related articles - All 3 versions
- ►iovs.org DM Gamm, JN Melvan, RL Shearer, I Pinilla, … - Investigative Ophthalmology & Visual Science, 2008 - ARVO PURPOSE. Established techniques for culturing primary human retinal pigment
epithelial (RPE) cells have facilitated the laboratory investigation of this
multipurpose retinal cell layer. However, most culture methods involve the ... Cited by 4 - Related articles - BL Direct - All 3 versions
JV Glenn, H Mahaffy, K Wu, G Smith, R Nagai … - Investigative Ophthalmology & Visual Science, 2009 - ARVO PURPOSE. Advanced glycation end products (AGEs) accumulate during aging and have
been observed in postmortem eyes within the retinal pigment epithelium (RPE),
Bruch's membrane, and subcellular deposits (drusen). AGEs have been ... Cited by 4 - Related articles - All 2 versions
RM Brucklacher, KM Patel, HD VanGuilder, … - BMC medical genomics, 2008 - biomedcentral.com Using the streptozotocin-induced rat model of diabetes, levels of retinal
permeability, caspase activity, and gene expression were examined after 1 and 3
months of diabetes. Gene expression changes were identified by whole genome ... Cited by 4 - Related articles - Cached - All 6 versions
AM Pawlak, JV Glenn, JR Beattie, JJ McGarvey … - Annals of the New York Academy of Sciences, 2008 - interscience.wiley.com The retina is exquisitely sensitive to age-related processes, and, in many
cases, these can precipitate progressive and profound loss of vision. Many
asymptomatic abnormalities that accrue in the outer retina as we get older ... Cited by 1 - Related articles - BL Direct - All 7 versions
A Stirban, P Rösen, D Tschoepe - Mount Sinai Journal of Medicine: A Journal of …, 2008 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 1 - Related articles - All 2 versions
JV Glenn, AW Stitt - BBA-General Subjects, 2009 - Elsevier The formation of advanced glycation end products (AGEs) is a natural function of
ageing but accumulation of these adducts also represents a key
pathophysiological event in a range of important human diseases. AGEs act ... Related articles - All 2 versions
