TD Brumeanu, R Goldstein, S Casares - Clinical Immunology, 2006 - Elsevier The inhibitors of HMG CoA reductase (statins) are widely used as
cholesterol-lowering drugs with excellent safety records in hypercholesterolemic
patients. Statins exert pleiotropic effects on a variety of cells, and they ... Cited by 12 - Related articles - All 4 versions
PT Brinkkoetter, U Gottmann, J Schulte, FJ … - Clinical and Experimental Immunology, 2006 - pubmedcentral.nih.gov Although a beneficial effect of hydroxy-methylglutaryl coenzyme A (HMG-CoA)
reductase inhibitors, ie statins, on cell-mediated immunity has been suggested
in vivo and in vitro, little is known about the molecular and biochemical ... Cited by 7 - Related articles - BL Direct - All 6 versions
- ►iovs.org NA Rao, S Saraswathy, GS Wu, GS Katselis, … - Investigative Ophthalmology & Visual Science, 2008 - ARVO METHODS. Gene microarrays were first used to identify upregulated genes in
retinas with early EAU. Among highly upregulated crystallins, A was confirmed by
real-time polymerase chain reaction and Western blot, and the site of ... Cited by 5 - Related articles - BL Direct - All 2 versions
S Yeh, LJ Faia, RB Nussenblatt - Seminars in Immunopathology, 2008 - Springer Abstract Significant advances in the diagnosis and therapy for uveitis have been
made to improve the quality of care for patients with ocular inflammatory
diseases. While traditional ophthalmic examination techniques, fluorescein ... Cited by 4 - Related articles - BL Direct - All 3 versions
AL Vallochi, AG Commodaro, JP Schwartzman, … - Cytokine and Growth Factor Reviews, 2007 - Elsevier The eye is a unique place for the development of an immune response. Beyond the
usual mechanisms of immune restraint, the eye evolved with its exclusive
mechanisms such as anterior chamber associated immune deviation. Therefore, ... Cited by 3 - Related articles - All 13 versions
MS Weber, O Stuve, O Neuhaus, H Hartung, … - International MS Journal, 2007 - msforum.net Introduction Statins are oral inhibitors of the 3-hydroxy-3- methylglutaryl
coenzyme A (HMG-CoA) reductase which are widely prescribed to lower cholesterol.
The enzyme HMG-CoA reductase catalyzes the conversion of HMG-CoA to ... Cited by 3 - Related articles - View as HTML - BL Direct - All 2 versions
C Ulivieri, D Fanigliulo, D Benati, FL Pasini, … - European Journal of Immunology, 2008 - interscience.wiley.com Statins block the activity of HMG-CoA reductase, which catalyses the production
of mevalonate, an intermediate in cholesterol biosynthesis, which is also a
precursor of isoprenoids. In addition to lowering circulating cholesterol, ... Cited by 1 - Related articles - All 3 versions
E Haq, B Rohrer, N Nath, CE Crosson, I Singh - Journal of Ocular Pharmacology and Therapeutics, 2007 - liebertonline.com Purpose: Experimental autoimmune uveitis (EAU), an animal model of human
uveitis, is an organ-specific autoimmune disease mediated by various
inflammatory cytokines. In par- ticular, tumor necrosis factor (TNF)- , ... Cited by 1 - Related articles - BL Direct - All 4 versions
SC Chow - Archivum Immunologiae et Therapiae Experimentalis, 2009 - Springer Statins are inhibitors of the enzyme 3-hydroxy-3methylglutaryl coenzyme A
(HMG-CoA) and they are the most effective agents for lowering cholesterol in
clinical practice for the treatment of cardiovascular diseases. However, it ... Related articles - All 2 versions
F Montecucco, F Mach - Seminars in immunopathology, 2009 - Springer Abstract Anti-inflammatory activities of statins in athero- sclerosis have been
well documented by both basic research and clinical studies. Statins have been
introduced in the 1980s as 3-hydroxy-3-methylglutaryl coenzyme A reductase ... Cited by 2 - Related articles - All 3 versions
