I Buhaescu, H Izzedine, A Covic - Therapeutic drug monitoring, 2006 - journals.lww.com Abstract: Sirolimus is a potent immunosuppressant drug with a novel mechanism of
action. It inhibits the mammalian target of rapamycin (mTOR) and blocks the cell
cycle of various cell types, including T- and B-lymphocytes. Sirolimus is ... Cited by 22 - Related articles - BL Direct - All 6 versions
S Muñoz-Fernández, E Martín-Mola - Best Practice & Research Clinical Rheumatology, 2006 - Elsevier Uveitis is a prevalent disease that mainly affects young people. It leads to a
significant number of visual losses. Acute anterior uveitis is the most
prevalent form, and it is often associated with spondyloarthritides in ... Cited by 15 - Related articles - All 4 versions
A Joseph, D Raj, V Shanmuganathan, RJ … - British Medical Journal, 2007 - bjo.bmj.com Background: Unlike the immune privilege enjoyed by low-risk corneal grafts,
high-risk corneal grafts experience rejection rates comparable to liver and
kidney transplants. Systemic immunosuppression reduces the risk of ... Cited by 9 - Related articles - BL Direct - All 4 versions
FR Imrie, AD Dick - Current Opinion in Ophthalmology, 2007 - journals.lww.com Purpose of review This review summarizes current nonsteroidal drug therapies for
noninfectious posterior and intermediate uveitis. Recent findings Continuing
evidence shows that second-line agents including antimetabolites, T-cell ... Cited by 9 - Related articles - BL Direct - All 2 versions
S Kashani, AA Mearza - Expert Opin. Drug Saf., 2008 - informahealthcare.com Ciclosporin is a calcineurin inhibitor that acts by primarily inhibiting the
action of T cells. Clinical trials in the early 1980s demonstrated that systemic
ciclosporin was a promising steroid-sparing agent and was also effective in ... Cited by 6 - Related articles - BL Direct - All 5 versions
RPA Manzano, GA Peyman, P Khan, M … - Arquivos Brasileiros de Oftalmologia, 2009 - SciELO Brasil Rapamycin (sirolimus; AG Scientific, San Diego, CA) is a cyclic macrolide
antibiotic isolated from the fungus Streptomyces hygroscopicus (1) . It is a
potent immunosuppressive agent, clinically approved for prevention of organ ... Cited by 1 - Related articles - Cached - All 6 versions
ME Zannin, F Zulian - Future Rheumatol., 2008 - Future Medicine Chronic anterior uveitis is the most important extra-articular complication of
juvenile idiopathic arthritis. It is more frequent in the early-onset forms,
with a higher prevalence in the oligoarticular subtype, and bilateral in ... Related articles - All 8 versions
LC Douglas, NY Yi, JL Davis, JH Salmon, BC … - Journal of Veterinary Pharmacology and Therapeutics, 2008 - interscience.wiley.com In vitro photosensitivity of rapamycin (RAPA) and ocular toxicity and
distribution of intravitreal and subconjunctival RAPA was evaluated in normal
horses. RAPA (2.5 mg, 5 mg, and 10 mg) was placed in 10 mL of PBS and ... Related articles - All 3 versions
- ►scielo.br RPA MANZANO… - Arq. Bras. Oftalmol - SciELO Brasil Rapamycin (sirolimus; AG Scientific, San Diego, CA) is a cyclic macrolide
antibiotic isolated from the fungus Streptomyces hygroscopicus (1) . It is a
potent immunosuppressive agent, clinically approved for prevention of organ ... Related articles - Cached
