MC Raff, AV Whitmore, JT Finn - Science, 2002 - sciencemag.org Neurons seem to have at least two self-destruct programs. Like other cell types,
they have an intracellular death program for undergoing apoptosis when they are
injured, infected, or not needed. In addition, they apparently have a ... Cited by 215 - Related articles - BL Direct - All 5 versions
RT Libby, Y Li, OV Savinova, J Barter, RS … - PLoS Genet, 2005 - genetics.plosjournals.org In glaucoma, harmful intraocular pressure often contributes to retinal ganglion
cell death. It is not clear, however, if intraocular pressure directly insults
the retinal ganglion cell axon, the soma, or both. The pathways that ... Cited by 61 - Related articles - Cached - All 12 versions
- ►nih.gov [PDF] - Free from Publisher NN OSBORNE, J MELENA, G CHIDLOW, … - British Journal of Ophthalmology, 2001 - bjo.bmj.com Raised IOP is not the sole factor responsible for glaucomatous retinal damage
but an important one of a number that have been implicated (Fig 1).12-17 Only
10% of patients with increased IOP (⩾22 mm Hg) have glaucoma and between ... Cited by 58 - Related articles - BL Direct - All 14 versions
M Ugarte, NN Osborne - Progress in Neurobiology, 2001 - Elsevier Experimental evidence exists to suggest that zinc can have positive and negative
effects on the physiology of cells depending on the 'local' concentration,
localisation (extracellular vs. intracellular) and/or state (bound vs. ... Cited by 55 - Related articles - BL Direct - All 6 versions
- ►iovs.org MR Steele, DM Inman, DJ Calkins, PJ Horner, … - Investigative ophthalmology & visual science, 2006 - ARVO METHODS. IOP was monitored monthly in DBA/2J animals, and animals with normal (3
months) or elevated IOP (8 months) were identified. RNA was prepared from three
individual retinas at each age, and the RNA was amplified and used to ... Cited by 46 - Related articles - BL Direct - All 4 versions
RT LIBBY, MG ANDERSON, IOKHOU PANG, … - Visual Neuroscience, 2005 - Cambridge Univ Press Abstract The glaucomas are neurodegenerative diseases involving death of retinal
ganglion cells and optic nerve head excavation. A major risk factor for this
neurodegeneration is a harmfully elevated intraocular pressureIOP!. Human ... Cited by 44 - Related articles - BL Direct - All 3 versions
EM Ullian, WB Barkis, S Chen, JS Diamond, … - Molecular and Cellular Neuroscience, 2004 - Elsevier NMDA excitotoxicity has been proposed to mediate the death of retinal ganglion
cells (RGCs) in glaucoma and ischemia. Here, we reexamine the effects of
glutamate and NMDA on rat RGCs in vitro and in situ. We show that highly ... Cited by 39 - Related articles - All 5 versions
- ►iovs.org B Fortune, MA Bearse Jr, GA Cioffi, CA … - Investigative ophthalmology & visual science, 2002 - ARVO METHODS. mfERGs of 16 individuals with glaucoma (POAG) and 18 normal control
subjects were recorded and analyzed with a VER imaging system. The stimulus had
three frames inserted between each m-sequence step: a full-field dark frame ... Cited by 38 - Related articles - BL Direct - All 4 versions
JPM Wood, KG Schmidt, J Melena, G Chidlow, … - Experimental Eye Research, 2003 - Elsevier In the present study it is shown that the non-selective β-adrenoceptor
antagonists, metipranolol and timolol behave like betaxolol. When topically
applied they all attenuate the detrimental effect of ischemia-reperfusion. ... Cited by 33 - Related articles - BL Direct - All 4 versions
