M Stumvoll, N Nurjhan, G Perriello, G Dailey, … - New England Journal of Medicine, 1995 - content.nejm.org Results Metformin treatment decreased the mean (±SD) glycosylated hemoglobin
value from 13.2±2.2 percent to 10.5±1.6 percent (P<0.001) and reduced fasting
plasma glucose concentrations from 220±41 to 155±28 mg per deciliter ... Cited by 461 - Related articles - All 6 versions
MB Davidson, AL Peters - The American journal of medicine, 1997 - Elsevier Type 2 diabetes mellitus results from impaired insulin secretion and reduced
peripheral insulin sensitivity. Treatment options include diet, oral
antihyperglycemic agents, and insulin. Metformin, an oral biguanide, ... Cited by 113 - Related articles - BL Direct - All 7 versions
KH Yuen, KK Peh - Journal of Chromatography B: Biomedical Sciences and …, 1998 - Elsevier A simple high-performance liquid chromatographic method using ultraviolet
detection was developed for the determination of metformin in human plasma. The
method entailed direct injection of the plasma sample after deproteination ... Cited by 62 - Related articles - All 4 versions
BE Wiholm, M Myrhed - European journal of clinical pharmacology, 1993 - Springer Summary. Since the withdrawal of phenformin in 1978, the use of metformin has
increased from 13,500 to 22,00patient years/year. During the period 1977-91 a
total of 18 cases of metformin - associated acidosis was re- ported, of ... Cited by 60 - Related articles - BL Direct - All 3 versions
JZ Song, HF Chen, SJ Tian, ZP Sun - Journal of Chromatography B: Biomedical Sciences and …, 1998 - Elsevier A capillary electrophoresis method was described for the determination of
metformin in human plasma based on the extraction of the ion-pair with
bromothymol blue into chloroform. Phenformin was used as internal standard. ... Cited by 39 - Related articles - All 5 versions
F Féry, L Plat, EO Balasse - Metabolism, 1997 - Elsevier To analyze the effects of metformin (M) on the kinetics and pathways of glucose
utilization after glucose ingestion, nine non-insulin-dependent diabetes
mellitus (NIDDM) patients underwent two 5-hour oral glucose tolerance tests ... Cited by 26 - Related articles - BL Direct - All 5 versions
G Caillé, Y Lacasse, M Raymond, H Landriault, M … - BIOPHARMACEUTICS AND DRUG DISPOSITION, 1993 - interscience.wiley.com Twenty-four young healthy volunteers received a single dose of metformin 500 mg
(Glucophage®, Nordic Laboratories, Canada) in tablet form. Plasma
concentrations were determined by HPLC in samples collected prior to and ... Cited by 17 - Related articles - BL Direct - All 3 versions
TME Davis, D Jackson, WA Davis, DG Bruce, … - British journal of clinical pharmacology, 2001 - pubmedcentral.nih.gov Metformin-treated patients had higher plasma lactate concentrations than
nonmetformin-treated subjects (geometric mean [sd range] 1.86 [1.34–2.59] vs
1.58 [1.09–2.30] mmol l −1 , respectively; P < 0.001). In a linear ... Cited by 17 - Related articles - BL Direct - All 6 versions
EJ Meuillet, N Wiernsperger, B Mania-Farnell … - European journal of pharmacology, 1999 - Elsevier The effects of the biguanide anti-hyperglycemic agent, metformin
(N,N′-dimethyl-biguanide), on insulin signaling was studied in a human
hepatoma cell line (HepG2). Cells were cultured in the absence (control ... Cited by 13 - Related articles - All 5 versions
F Purrello, D Gullo, M Buscema, V Pezzino, R … - Diabetologia, 1988 - Springer Summary. The effect of the oral antidiabetic agent metformin on insulin
regulation of glycogen metabolism, tyrosine-ami- notransferase activity, and
[1-4C]aminoisobutyric acid up- take was studied in H4IIE cultured rat ... Cited by 11 - Related articles - All 4 versions
