- ►annals.org [PDF] RA DeFronzo - Annals of internal medicine, 1999 - Am Coll Physicians Type 2 diabetes mellitus is a chronic metabolic disorder that results from
defects in both insulin secretion and insulin action. An elevated rate of basal
hepatic glucose production in the presence of hyperinsulinemia is the pri- ... Cited by 784 - Related articles - BL Direct - All 14 versions
M Stumvoll, N Nurjhan, G Perriello, G Dailey, … - New England Journal of Medicine, 1995 - content.nejm.org Results Metformin treatment decreased the mean (±SD) glycosylated hemoglobin
value from 13.2±2.2 percent to 10.5±1.6 percent (P<0.001) and reduced fasting
plasma glucose concentrations from 220±41 to 155±28 mg per deciliter ... Cited by 461 - Related articles - All 6 versions
RA DeFronzo, AM Goodman… - New England Journal of Medicine, 1995 - content.nejm.org Results In protocol 1, at the end of the study the 143 patients in the metformin
group, as compared with the 146 patients in the placebo group, had lower mean
(±SE) fasting plasma glucose concentrations (189±5 vs. 244±6 mg per ... Cited by 440 - Related articles - All 7 versions
RS Savkur, AV Philips, TA Cooper - Nature genetics, 2001 - ym.edu.tw Myotonic dystrophy type 1 (DM1) is caused by a CTG trinucleotide expansion in
the 3′ untranslated region of the DM protein kinase gene. People with DM1 have
an unusual form of insulin resistance caused by a defect in skele- tal ... Cited by 250 - Related articles - View as HTML - BL Direct - All 8 versions
MD Garber, J Alan, MD Duncan, G Theodore, … - The American journal of medicine, 1997 - Elsevier RESULTS: Metformin improved glucose variables as compared with placebo. The
adjusted mean changes in fasting plasma glucose from baseline associated with
each metformin group at week 7, 11, or at endpoint exceeded those ... Cited by 234 - Related articles - BL Direct - All 4 versions
- ►endojournals.org S Matthaei, M Stumvoll, M Kellerer, HU Haring - Endocrine Reviews, 2000 - Endocrine Soc Diabetes mellitus type 2 is a world-wide growing health problem affecting more
than 150 million people at the beginning of the new millennium. It is believed
that this number will double in the next 25 yr. The pathophysiological ... Cited by 205 - Related articles - BL Direct - All 5 versions
- ►endojournals.org V De Leo, A la Marca, F Petraglia - Endocrine reviews, 2003 - Endocrine Soc Polycystic ovary syndrome (PCOS) is a medical condition that has brought
multiple specialists together. Gynecologists, endocrinologists, cardiologists,
pediatricians, and dermatologists are all concerned with PCOS patients and ... Cited by 130 - Related articles - BL Direct - All 4 versions
MB Davidson, AL Peters - The American journal of medicine, 1997 - Elsevier Type 2 diabetes mellitus results from impaired insulin secretion and reduced
peripheral insulin sensitivity. Treatment options include diet, oral
antihyperglycemic agents, and insulin. Metformin, an oral biguanide, ... Cited by 113 - Related articles - BL Direct - All 7 versions
GS Roth, DK Ingram, MA Lane - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2001 - interscience.wiley.com Abstract: Dietary caloric restriction (CR) is the only intervention conclusively
and reproducibly shown to slow aging and maintain health and vitality in
mammals. Although this paradigm has been known for over 60 years, its ... Cited by 114 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] V Sarabia, L Lam, E Burdett, LA Leiter, A Klip - Journal of Clinical Investigation, 1992 - pubmedcentral.nih.gov Primary human muscle cell cultures were established and the regulation of
glucose transport was investigated. Primary cul- tures were allowed to proceed
to the stage of myotubes through fusion of myoblasts or were used for ... Cited by 81 - Related articles - BL Direct - All 5 versions
