- ►nih.gov [PDF] MG Ehm, MC Karnoub, H Sakul, K Gottschalk, … - The American Journal of Human Genetics, 2000 - Elsevier Type 2 diabetes is a serious, genetically influenced disease for which no fully
effective treatments are available. Identification of biochemical or regulatory
pathways involved in the disease syndrome could lead to innovative ... Cited by 113 - Related articles - BL Direct - All 5 versions
KK Steinberg, KC Sanderlin, CY Ou, WH … - Epidemiologic reviews, 1997 - Soc Epidemiolc Res Advances in genetic technology, such as the poly- merase chain reaction (PCR)
(1) and the work of the Human Genome Project to map and sequence the human
genome (2-4), are expediting our understand- ing of the genetic ... Cited by 92 - Related articles - BL Direct - All 10 versions
L Henkin, RN Bergman, DW Bowden, DL … - Annals of epidemiology, 2003 - Elsevier METHODS: Families from two ethnic groups (African American and Hispanic) have
been recruited from three clinical sites. Blood samples for DNA as well as other
standard measures were collected. A CT scan (visceral adiposity) and a ... Cited by 67 - Related articles - All 4 versions
- ►endojournals.org SJ Hasstedt, QF Ren, K Teng, SC Elbein - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc The Pro 12 Ala (P12A) variant of exon B of the peroxisome proliferator-activated
receptor 2 (PPAR ) been variably associated with obesity, insulin sensitivity,
diabetes, and dyslipidemia, but its role in insulin resistance-associated ... Cited by 67 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] KC Chiu, P Cohan, NP Lee, LM Chuang - Diabetes Care, 2000 - Am Diabetes Assoc Type 2 diabetes is an imbalance between -cell function and insulin sensitivity
(9). Because both -cell dysfunction and insulin resistance have been shown to be
inherited defects (10–12), either defect could account for the ethnic ... Cited by 58 - Related articles - BL Direct - All 5 versions
KC Chiu, LM Chuang, NP Lee, JM Ryu, JL … - Metabolism, 2000 - Elsevier [24]. G Hedbeack and A Odaen, Increased risk of death from primary
hyperparathyroidism-an update. Eur J Clin Invest 28 (1998), pp. 271–276. ...
[35]. GZ Fadda, M Akmal, LG Lipson et al., Direct effect of parathyroid ... Cited by 47 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org CC Jensen, M Cnop, RL Hull, WY Fujimoto, … - Diabetes, 2002 - Am Diabetes Assoc First-degree relatives of individuals with type 2 diabetes are at increased risk
of developing hyperglycemia. To examine the prevalence and pathogenesis of
abnormal glucose homeostasis in these subjects, 531 first-degree relatives ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►nih.gov MP Stern - Journal of Clinical Investigation, 2000 - Am Soc Clin Investig In this paper I review the evidence that human sensitivity to insulin is
influenced by heredity, in particular by one or more genes with relatively large
effects. Even granting the existence of such genes, however, the best route ... Cited by 43 - Related articles - BL Direct - All 10 versions
KC Chiu, NP Lee, P Cohan, LM Chuang - Clinical Endocrinology, 2000 - ingentaconnect.com OBJECTIVE As type 2 diabetes results from an imbal- ance between insulin
sensitivity and beta cell func- tion, either or both may worsen with age.
However, existing data are controversial on the effect of ageing on both ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org SC Elbein, J Sun, E Scroggin, K Teng, SJ … - Diabetes Care, 2001 - Am Diabetes Assoc OBJECTIVE—We have demonstrated high heritability of insulin secretion measured
as acute insulin response to glucose times insulin sensitivity (disposition
index). Furthermore, we showed that obese normoglycemic family members of a ... Cited by 31 - Related articles - BL Direct - All 5 versions
