J Brange, A Vølund - Advanced drug delivery reviews, 1999 - Elsevier The aim of insulin replacement therapy is to normalize blood glucose in order to reduce the complications
of diabetes. The pharmacokinetics of the traditional insulin preparations, however, do not match
the profiles of physiological insulin secretion. The introduction of the rDNA technology 20 ... Cited by 128 - Related articles - All 5 versions
- ►endojournals.org Z Vajo, J Fawcett, WC Duckworth - Endocrine reviews, 2001 - Endocrine Soc After more than half a century of treating diabetics with animal insulins, recombinant DNA technologies
and advanced protein chemistry made human insulin preparations available in the early
1980s. As the next step, over the last decade, insulin analogs were constructed by ... Cited by 62 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org Z Vajo, WC Duckworth - Pharmacological reviews, 2000 - ASPET Tight glucose control is essential to minimize complications in diabetic patients. However, the
pharmacokinetic characteristics of the currently available rapid-, intermediate-, and long-acting
preparations of human insulin make it almost impossible to achieve sustained ... Cited by 56 - Related articles - BL Direct - All 4 versions
RP Radermecker, AJ Scheen - Diabetes/Metabolism Reviews - interscience.wiley.com Portable insulin infusion devices are effective and safe insulin delivery systems for managing
diabetes mellitus, especially type 1 diabetes. Rapidly absorbed insulin analogues, such as insulin
lispro or insulin aspart, may offer an advantage over regular human insulin for insulin ... Cited by 50 - Related articles - BL Direct - All 3 versions
G Emilien, JM Maloteaux, M Ponchon - Pharmacology and Therapeutics, 1999 - Elsevier Glycaemic control in Type 1 diabetes has been proven efficient in preventing microvascular and
neurological complications. The assumption that good control of hyperglycaemia may also have
significant impact on alleviation of complications in Type 2 diabetes has gained growing ... Cited by 25 - Related articles - BL Direct - All 4 versions
I Guilhem, AM Leguerrier, F Lecordier, JY Poirier, D … - Diabetes and Metabolism, 2006 - Elsevier Most reports on technical faults, often leading to metabolic emergencies, mainly
ketoacidosis, have been published in the 1980s. Obstruction of infusion set and infection of infusion
site are the most frequent events. Insulin precipitation or aggregation is thought to be one ... Cited by 19 - Related articles - BL Direct - All 3 versions
- ►nih.gov [PDF] HA Wolpert, RN Faradji, S Bonner-Weir, … - BMJ: British Medical …, 2002 - pubmedcentral.nih.gov Abortion on request has been legal in South Africa since 1997. The Choice in Termination of
Pregnancy Act of South Africa 1996 allows abortion on request up to 20 weeks' gestation. Since
it was introduced, 40 000 legal abortions have been performed annually.1 A national ... Cited by 17 - Related articles - BL Direct - All 6 versions
Y Matsuo, S Shimoda, M Sakakida, K Nishida, T … - Journal of Artificial …, 2003 - Springer Y. Matsuo · S. Shimoda · M. Sakakida (*) · K. Nishida · T. Sekigami · S. Ichimori · K. Ichinose ·
E. Araki Department of Metabolic Medicine, Kumamoto University School of Medicine, 1-1-1
Honjo, Kumamoto 860-8556, Japan Tel. 81-96-373-5169; Fax 81-96-366-8397 e-mail: ... Cited by 14 - Related articles - BL Direct - All 3 versions
LR Reynolds - SOUTHERN MEDICAL JOURNAL-BIRMINGHAM …, 2000 - pdfs.journals.lww.com EXTERNAL INSULIN infusion pumps became gen- erally available in the early 1980s, after initial
studies suggested that normalization of blood glucose levels was possible in difficult-to-man-
age cases of insulin deficiency.1-4 Pump therapy was widely applied to the most difficult ... Cited by 14 - Related articles - BL Direct - All 9 versions
RP Radermecker, AJ Scheen - Diabetes/Metabolism Reviews - interscience.wiley.com The purification of animal insulin preparations and the use of human recombinant insulin have
markedly reduced the incidence but not completely suppressed the occurrence of insulin allergy
manifestations. Advances in technologies concerning the mode of delivery of insulin, ie ... Cited by 13 - Related articles - BL Direct - All 3 versions
